Arterial Hypertension and Risk of Mortality in Patients with COVID-19 Infection (CROSBI ID 309642)
Prilog u časopisu | stručni rad | međunarodna recenzija
Podaci o odgovornosti
Bukal, Nikolina ; Kolarić, Melanija ; Golubić, Ines ; Josipović, Josipa ; Premužić, Vedran ; Jelakovic, Ana ; Karanović, Sandra ; Bašić Jukić, Nikolina ; Jelaković, Bojan
engleski
Arterial Hypertension and Risk of Mortality in Patients with COVID-19 Infection
COVID-19 is currently a major global health concern. Among many unanswered questions related to COVID-19, some of the most debated ones are those concerning arterial hypertension. Arterial hypertension is a major risk factor for mortality worldwide and its importance has been emphasised even further in light of COVID-19. The most common antihypertensive drugs are ACE inhibitors and angiotensin II type-I receptor blockers. SARS-CoV- 2 utilises the angiotensin- converting enzyme-2 (ACE2) for cell entry and therefore has a direct effect on the renin– angiotensin system (RAS). In terms of arterial hypertension and COVID-19, there are three main issues which have been the focus of extensive debates. First, is arterial hypertension a predisposing factor for COVID-19 infection? Second, does arterial hypertension affect the severity of COVID-19 infection and increase the risk of all-cause and cardiovascular mortality? And finally, how important is the interaction of COVID-19 infection and the renin–angiotensin system for clinical outcomes? Is RAS blockade beneficial or harmful? The aim of this brief review was to provide substantiated answers to these questions.
arterial hypertension ; COVID-19 infection ; renin-angiotensin system
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Podaci o izdanju
6 (1)
2022.
74-82
objavljeno
2459-9484
10.26332/seemedj.v6i1.239