engleski

Aggressive prolactinoma of young man with enormous mass of amyloid deposits

This report presents a rare type of aggressive prolactinoma with enormous mass of spheroidal amyloid deposits with scarce cellular tumor tissue and without hormonal serological data at the moment of pathological diagnostic procedure. In pituitary gland and pituitary adenomas different type of amyloid deposits may be found. Incidence of amyloid deposits found in pituitary adenomas is not low, but spheroidal type of amyloid deposits is rarely present. This type of amyloid is called endocrine amyloid, but there are different opinions about its origin, so this problem remains unsolved. A 28-year-old man, without previous medical history, was admitted due to visual disturbance and headaches, which lasted for about a month. Magnetic resonance imaging (MRI) showed a large lesion in the sellar and suprasellar region with progression toward the sphenoidal sinus. Patient underwent surgery. Pathohistological analysis of intraoperative and postoperative samples determined an enormous mass of eosinophilic spheroidal material and scanty cellular tissue consisted of polymorphous and hyperchromatic cells. Immunohistochemical staining for prolactin was positive in tumor&#8217 ; s cells and partially positive in spheroidal deposits. Amyloid was proved in those deposits with Congo-red staining. Other immunostaining as CK, Chr-A and Ki-67 was slightly positive in tumor&#8217 ; s cells, while GH and CEA immunostaining was negative. Prolactin-positive immunostaining of amyloid deposits may question the opinion that amyloid is produced by adenoma &#8216 ; s cells. Prolactinomas are usually tumors of middle aged men. In this case report we present a young man with specific histological findings. Reviewing the literature we came across only 13 published cases, including two personal observations.

prolactinoma; mass of amyloid deposits

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