engleski

Possible influence of the war agression on Croatia (1991-1995) on distribution of skin cancer

Aim of this investigation was to evaluate significance of social difficulties and stress, induced by war activities in the region, as risk factors in development of precancerous and cancerous skin lesions. In this study we analyze and compare incidence, sex distribution and age dependent characteristics in patients with precancerous (keratosis solaris and Bowen&#8217 ; s disease) and cancerous (basal cell carcinoma, squamous cell carcinoma and melanoma) skin lesions. In our department, skin cancer registry was created using pathological and clinical data of patients with skin tumor biopsies during the eleven year period (1989- 1999). We investigated pre-war data (1989- 1990) and post-war data (1997- 1999 ) in Croatia. There were 714 above mentioned skin tumor biopsies in pre-war period (1989- 1990) (3.43 % of total department biopsies) from which 77 precancerous lesions biopsies (0.37 % of total department biopsies) and 637 cancerous lesions biopsies (3.06 % of total department biopsies). The histologic type distribution in pre-war period (1989- 1990) was for basal cell carcinoma 471 (66 %) biopsies with M/F ratio 1:1 ; squamous cell carcinoma in 136 (19 %) biopsies with M/F ratio 1.6:1 ; keratosis solaris in 70 (9.8%) biopsies with M/F ratio 1:1.1 ; melanoma in 30 (4.2%) biopsies with M/F ratio 1:1.5 ; and Bowen&#8217 ; s disease in 7 (1%) biopsies with M/F ratio 1.1:1.3. The mean age at the time of diagnosis in pre-war period (1989.- 1990.) was for basal cell carcinoma 66 years, for squamous cell carcinoma 71 years, for keratosis solaris 67 years, for melanoma 60 years and for Bowen&#8217 ; s disease 70 years. In postwar period (1997-1999) there were 1082 biopsies (2.75 % of total department biopsies) from which 175 were precancerous lesions biopsies (0.44 % of total department biopsies) and 914 cancerous lesions biopsies (2.32 % of total department biopsies). The histologic type distribution in post-war period (1997- 1999) was for basal cell carcinoma 711 (65.7%) biopsies with M/F ratio 1:1 ; keratosis solaris in 168 (15.5%) biopsies with M/F ratio 1.1:1 ; squamous cell carcinoma in 140 (12 % ) biopsies with M/F ratio 1.4:1 ; melanoma in 76 (7%) biopsies with M/F ratio 1:1 ; and Bowen&#8217 ; s disease in 7 (0.7 % ) biopsies with M/F ratio 1.3:1. The mean age at the time of diagnosis in post-war period (1997- 1999) was for basal cell carcinoma 68.5, for keratosis solaris 67 years, for squamous cell carcinoma 70 years, for melanoma 58 years and for Bowen&#8217 ; s disease 72.5 years. This data shows an increase of melanoma from 4.2 % in pre-war period (1989- 1990) to 7 % in post-war period (1997- 1999), keratosis solaris from 9.8 % to 15.5 % and a decrease of squamous cell carcinoma from 19 % to 12 % in the skin cancer data bases.

skin cancer; influence of the war

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