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Pregled bibliografske jedinice broj: 1193809

Synthesis of 14-membered enediyne-embedded macrocycles


Glavaš, Mladena; Gredičak, Matija; Štefanić, Zoran; Jerić, Ivanka
Synthesis of 14-membered enediyne-embedded macrocycles // Organic & biomolecular chemistry, 20 (2022), 18; 3823-3834 doi:10.1039/d2ob00090c (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1193809 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis of 14-membered enediyne-embedded macrocycles

Autori
Glavaš, Mladena ; Gredičak, Matija ; Štefanić, Zoran ; Jerić, Ivanka

Izvornik
Organic & biomolecular chemistry (1477-0520) 20 (2022), 18; 3823-3834

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
enediyne structural unit ; macrocycles ; Ugi/Sonogashira reactions

Sažetak
A concise and practical strategy towards a novel class of 14-membered macrocycles containing an enediyne(Z-3-ene-1, 5-diyne) structural unit is described. A highly modular assembly of various precursors via sequential Ugi/Sonogashira reactions allowed the preparation of hybrid enediyne-peptide macrocycles in most cases as single diastereoisomers. Selected macrocyclic compounds showed moderate antiproliferative activity, and can be considered as templates suitable for further diversification in terms of ring size, shape, and stereochemistry.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-3102 - Višekomponentne reakcije u sintezi peptidnih mimetika (MIMICRy) (Jerić, Ivanka, HRZZ - 2014-09) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi pubs.rsc.org doi.org

Citiraj ovu publikaciju:

Glavaš, Mladena; Gredičak, Matija; Štefanić, Zoran; Jerić, Ivanka
Synthesis of 14-membered enediyne-embedded macrocycles // Organic & biomolecular chemistry, 20 (2022), 18; 3823-3834 doi:10.1039/d2ob00090c (međunarodna recenzija, članak, znanstveni)
Glavaš, M., Gredičak, M., Štefanić, Z. & Jerić, I. (2022) Synthesis of 14-membered enediyne-embedded macrocycles. Organic & biomolecular chemistry, 20 (18), 3823-3834 doi:10.1039/d2ob00090c.
@article{article, author = {Glava\v{s}, Mladena and Gredi\v{c}ak, Matija and \v{S}tefani\'{c}, Zoran and Jeri\'{c}, Ivanka}, year = {2022}, pages = {3823-3834}, DOI = {10.1039/d2ob00090c}, keywords = {enediyne structural unit, macrocycles, Ugi/Sonogashira reactions}, journal = {Organic and biomolecular chemistry}, doi = {10.1039/d2ob00090c}, volume = {20}, number = {18}, issn = {1477-0520}, title = {Synthesis of 14-membered enediyne-embedded macrocycles}, keyword = {enediyne structural unit, macrocycles, Ugi/Sonogashira reactions} }
@article{article, author = {Glava\v{s}, Mladena and Gredi\v{c}ak, Matija and \v{S}tefani\'{c}, Zoran and Jeri\'{c}, Ivanka}, year = {2022}, pages = {3823-3834}, DOI = {10.1039/d2ob00090c}, keywords = {enediyne structural unit, macrocycles, Ugi/Sonogashira reactions}, journal = {Organic and biomolecular chemistry}, doi = {10.1039/d2ob00090c}, volume = {20}, number = {18}, issn = {1477-0520}, title = {Synthesis of 14-membered enediyne-embedded macrocycles}, keyword = {enediyne structural unit, macrocycles, Ugi/Sonogashira reactions} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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