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izvor podataka: crosbi

Synthesis of 14-membered enediyne-embedded macrocycles (CROSBI ID 309463)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Glavaš, Mladena ; Gredičak, Matija ; Štefanić, Zoran ; Jerić, Ivanka Synthesis of 14-membered enediyne-embedded macrocycles // Organic & biomolecular chemistry, 20 (2022), 18; 3823-3834. doi: 10.1039/d2ob00090c

Podaci o odgovornosti

Glavaš, Mladena ; Gredičak, Matija ; Štefanić, Zoran ; Jerić, Ivanka

engleski

Synthesis of 14-membered enediyne-embedded macrocycles

A concise and practical strategy towards a novel class of 14-membered macrocycles containing an enediyne(Z-3-ene-1, 5-diyne) structural unit is described. A highly modular assembly of various precursors via sequential Ugi/Sonogashira reactions allowed the preparation of hybrid enediyne-peptide macrocycles in most cases as single diastereoisomers. Selected macrocyclic compounds showed moderate antiproliferative activity, and can be considered as templates suitable for further diversification in terms of ring size, shape, and stereochemistry.

enediyne structural unit ; macrocycles ; Ugi/Sonogashira reactions

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Podaci o izdanju

20 (18)

2022.

3823-3834

objavljeno

1477-0520

1477-0539

10.1039/d2ob00090c

Povezanost rada

Kemija

Poveznice
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