miRNAs: A potentially valuable tool in pesticide toxicology assessment-current experimental and epidemiological data review (CROSBI ID 309404)
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Podaci o odgovornosti
Valencia-Quintana, Rafael ; Bahena-Ocampo, Iván Uriel ; González-Castañeda, Gerardo ; Bonilla, Edmundo ; Milić, Mirta ; Bonassi, Stefano ; Sánchez-Alarcón, Juana
engleski
miRNAs: A potentially valuable tool in pesticide toxicology assessment-current experimental and epidemiological data review
miRNAs are responsible for the regulation of many cellular processes such as development, cell differentiation, proliferation, apoptosis, and tumor growth. Several studies showed that they can also serve as specific, stable, and sensitive markers of chemical exposure. In this review, current experimental and epidemiological data evidencing deregulation in miRNA expression in response to fungicides, insecticides or herbicides were analyzed. As shown by Venn's diagrams, miR- 363 and miR-9 deregulation is associated with fungicide exposure in vitro and in vivo, while let-7, miR-155, miR-181 and miR-21 were found to be commonly deregulated by at least three different insecticides. Furthermore, let-7, miR- 30, miR-126, miR-181 and miR-320 were commonly deregulated by 3 different herbicides. Notably, these 5 miRNAs were also found to be deregulated by one or more insecticides, suggesting their participation in the cellular response to pesticides, regardless of their chemical structure. All these miRNAs have been proposed as potential biomarkers for fungicide, insecticide, or herbicide exposure. These results allow us to improve our understanding of the molecular mechanisms of toxicity upon pesticide exposure, although further studies are needed to confirm these miRNAs as definitive (not potential) biomarkers of pesticide exposure.
let-7 ; miR- 9 ; miR-21 ; miR-155 ; miR-181 ; miR-363
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Podaci o izdanju
Povezanost rada
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Dentalna medicina, Farmacija, Javno zdravstvo i zdravstvena zaštita