In vitro susceptibility of carbapenem-resistant Enterobacterales to eravacycline – the first report from Croatia (CROSBI ID 309324)
Prilog u časopisu | kratko priopćenje | međunarodna recenzija
Podaci o odgovornosti
Jurić, Ivana ; Bošnjak, Zrinka ; Ćorić, Mario ; Lešin, Joško ; Mareković, Ivana
engleski
In vitro susceptibility of carbapenem-resistant Enterobacterales to eravacycline – the first report from Croatia
The main obstacle in treatment of infections caused by carbapenem-resistant Enterobacterales (CRE) are limited treatment options. The novel antimicrobial agents other than β-lactams with activity not being dependent on β-lactamase class are especially important. Eravacycline (ERV) is the first fully synthetic fluorocycline indicated for the treatment of complicated intra-abdominal infections in adults. Eighty CRE isolates at the University Hospital Centre Zagreb, Croatia were examined for susceptibility to ERV by disc diffusion method and minimal inhibitory concentration (MIC). Total of 54 (54/80 ; 67.5%) isolates were susceptible to ERV with MIC50 of ≤0.5 μg/mL and MIC90 of 4 μg/mL. Susceptibility of OXA-48 positive isolates was not significantly higher in comparison with NDM positive (P = 0.539) and VIM positive (P = 0.7805) isolates. ERV is possible alternative to novel β-lactamase inhibitor combinations for treatment of CRE infections with antimicrobial susceptibility testing of CRE isolate to ERV in particular patient as condicio sine qua non before administration.
carbapenem-resistant Enterobacterales (CRE) ; carbapenemases ; disc diffusion ; eravacycline ; in vitro susceptibility ; minimal inhibitory concentration ; β-lactamases
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Podaci o izdanju
34 (1)
2022.
67-70
objavljeno
1120-009X
1973-9478
10.1080/1120009x.2021.1965335
Povezanost rada
Kliničke medicinske znanosti