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izvor podataka: crosbi

DNA and RNA binding studies of novel amidine- and amidoxime-substituted heterocycles (CROSBI ID 717582)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Shanmugam, Suresh ; Radić Stojković, Marijana ; Maračić, Silvija ; Raić-Malić, Silvana DNA and RNA binding studies of novel amidine- and amidoxime-substituted heterocycles // 27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog: Book of Abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel et al. (ur.). Zagreb: Hrvatsko kemijsko društvo, 2021. str. 178-178

Podaci o odgovornosti

Shanmugam, Suresh ; Radić Stojković, Marijana ; Maračić, Silvija ; Raić-Malić, Silvana

engleski

DNA and RNA binding studies of novel amidine- and amidoxime-substituted heterocycles

DNA is a major target for a large number of anticancer drugs due to their crucial functions in cells. Based upon the antiproliferative activity, several compounds (Figure 1) from a series of novel amidine- and amidoxime-substituted heterocycles (Department of Organic Chemistry, Faculty of Chemical Engineering and Technology) were selected for the study with calf thymus DNA (ctDNA), alternating AT-DNA and AU-RNA. Assessing the binding strength and mode of binding of small molecule-DNA interactions was performed using UV / Vis, fluorescence and circular dichroism (CD) spectroscopy. All studied compounds showed a greater stabilization effect of AT-DNA compared to ctDNA and AU-RNA. Only a derivative possessing two imidazole moieties at the end of the heteroaromatic structure stabilizes both DNA and RNA. The addition of some compounds to DNA solutions caused, either an appearance of positive induced CD spectra (ICD) or small negative ICD signals. Such changes in CD spectra suggest binding inside the DNA groove (positive ICD) or intercalative binding where the ligand is oriented ''parallel'' to the long axis of adjacent base pairs (negative ICD).

DNA and RNA binding ; amidine-substituted heterocycles ; amidoxime-substituted heterocycles ; UV/Vis ; fluorescence ; circular dichroism

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Podaci o prilogu

178-178.

2021.

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objavljeno

Podaci o matičnoj publikaciji

27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog: Book of Abstracts

Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna

Zagreb: Hrvatsko kemijsko društvo

2757-0754

Podaci o skupu

27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI) ; 5. simpozij Vladimir Prelog

poster

05.10.2021-08.10.2021

Rovinj, Hrvatska

Povezanost rada

Kemija