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Association of Specific Genes Polymorphisms With Temporomandibular Disorders (CROSBI ID 717504)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Zlendić, Marko ; Vrbanović, Ema ; Gall Trošelj, Koraljka ; Tomljanović, Marko ; Alajbeg, Iva Association of Specific Genes Polymorphisms With Temporomandibular Disorders // Journal of dental research. 2022. str. x-x

Podaci o odgovornosti

Zlendić, Marko ; Vrbanović, Ema ; Gall Trošelj, Koraljka ; Tomljanović, Marko ; Alajbeg, Iva

engleski

Association of Specific Genes Polymorphisms With Temporomandibular Disorders

Objectives: Temporomandibular disorders (TMD) represent heterogeneous musculoskeletal conditions. Their complex etiology is yet to be thoroughly explored. The aim of the research presented is to investigate genetic predisposition as a risk factor for the TMD onset. Methods: Anamnestic and clinical data have been collected. Genomic DNA will be extracted from the buccal swabs obtained from TMD patients (DC/TMD) and control subjects, and used for the determination of selected polymorphisms by TaqMan SNP Genotyping Assays (Carlsbad, United States, Life Technologies). Gene polymorphisms clustering is expected to be related to the presence or absence of TMD. Whether specific clusters can be related to the source of pain and its intensity, presence of bone changes, psychological features, previous orthodontic therapy and treatment response to occlusal splint therapy will be explored. Results: We expect to show that a particular genotype may be a potential risk factor for the development of TMD. Conclusions: This innovative approach, focused on genetic predisposition for TMD has the potential for development of a commercial genetic test which would allow for risk estimation with respect to the TMD onset. Accordingly, it may be a potential tool to be used for decision making on early interventions and active avoidance of environmental risk factors.

temporomandibular disorders ; genetic risk factors ; polymorphisms

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Podaci o prilogu

x-x.

2022.

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objavljeno

Podaci o matičnoj publikaciji

Journal of dental research

0022-0345

1544-0591

Podaci o skupu

2022 AADOCR/CADR Annual Meeting & Exhibition

predavanje

21.03.2022-26.03.2022

Atlanta (GA), Sjedinjene Američke Države

Povezanost rada

Dentalna medicina