Pharmacogenetic distinction of the Croatian population from the European average. (CROSBI ID 309182)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Celinšćak, Željka ; Zajc Petranović, Matea ; Šetinc, Maja ; Stojanović Marković, Anita ; Peričić Salihović, Marijana ; Zeljko, Hrvojka Marija ; Janićijević, Branka ; Smolej Narančić, Nina ; Škarić-Jurić, Tatjana
engleski
Pharmacogenetic distinction of the Croatian population from the European average.
Aim: To compare the Croatian and European population in terms of allele frequencies of clinically relevant polymorphisms in drug absorption, distribution, metabolism, and excretion (ADME) genes. Methods: In 429 Croatian participants, we genotyped 27 loci in 20 ADME genes. The obtained frequencies were merged with the published frequencies for the Croatian population by sample size weighting. The study sample obtained in this way was compared with the average data for the European population from the gnomAD database. Results: Variant allele frequencies in the Croatian population were higher in three and lower in two polymorphisms (Benjamini-Hochberg-corrected P values: 0.0027 for CYP2B6*4 rs2279343, CYP2C9*2 rs1799853, and VKORC1 rs9923231 ; 0.0297 for GSTP1 rs1695 ; 0.0455 for CYP2A6 rs1801272) compared with the European population. The most marked difference was observed for CYP2B6*4 (9.3% in Europe vs 24.3% in Croatia). The most clinically relevant findings were higher variant allele frequencies in two polymorphisms related to lower warfarin requirements: VKORC1*2 (34.9% in Europe vs 40.1% in Croatia) and CYP2C9*2 (12.3% in Europe vs 14.7% in Croatia). This indicates that three- quarters of Croatian people have at least one variant allele at these loci. Variants in genes GSTP1 and CYP2A6 were significantly less frequently observed in Croatia. Conclusions: Croatian population has a higher bleeding and over-anticoagulation risk, which is why we recommend the prescription of lower doses of anticoagulation drugs such as warfarin and acenocoumarol. Lower phenytoin, and higher bupropion and efavirenz doses are also recommended in the Croatian population.
ADME ; Croatian population ; gnomAD ; population genetics ; pharmacotherapy ; drug–gene interaction ; anticoagulants ; warfarin
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Podaci o izdanju
63 (2)
2022.
117-125
objavljeno
0353-9504
1332-8166
10.3325/cmj.2022.63.117
Povezanost rada
Biologija, Etnologija i antropologija, Farmacija, Javno zdravstvo i zdravstvena zaštita