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The European/international fibromuscular dysplasia registry and initiative (FEIRI) - clinical phenotypes and their predictors based on a cohort of 1000 patients (CROSBI ID 309164)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Pappaccogli, Marco ; Di Monaco, Silvia ; Warchoł- Celińska, Ewa ; Lorthioir, Aurelien ; Amar, Laurence ; Aparicio, Lucas S ; Beauloye, Christophe ; Bruno, Rosa Maria ; Chenu, Patrick ; de Leeuw, Peter et al. The European/international fibromuscular dysplasia registry and initiative (FEIRI) - clinical phenotypes and their predictors based on a cohort of 1000 patients // Cardiovascular research, 117 (2021), 950-959. doi: 10.1093/cvr/cvaa102

Podaci o odgovornosti

Pappaccogli, Marco ; Di Monaco, Silvia ; Warchoł- Celińska, Ewa ; Lorthioir, Aurelien ; Amar, Laurence ; Aparicio, Lucas S ; Beauloye, Christophe ; Bruno, Rosa Maria ; Chenu, Patrick ; de Leeuw, Peter ; De Backer, Tine ; Delmotte, Philippe ; Dika, Živka ; Gordin, Daniel ; Heuten, Hilde ; Iwashima, Yoshio ; Krzesinski, Jean-Marie ; Kroon Abraham ; Mazzolai, Lucia ; Poch, Esteban ; Sarafidis, Pantelis ; Seinturier, Christophe ; Spiering, Wilko ; Toubiana, Laurent ; Van der Niepen, Patricia ; van Twist, Daan ; Visonà, Adriana ; Wautrecht, Jean- Claude ; Witowicz, Helena ; Xu, Jianzhong ; Prejbisz, Aleksander ; Januszewicz, Andrzej ; Azizi, Michel ; Persu, Alexandre

engleski

The European/international fibromuscular dysplasia registry and initiative (FEIRI) - clinical phenotypes and their predictors based on a cohort of 1000 patients

Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well as predic tors of widespread disease, aneurysms and dissections. All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on computed tomography angiography, magnetic resonance angiography, and/or catheter-based angiography were eligible. Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46 ± 16 years (12% >_65 years old), 86% were hypertensive, 72% had multifocal, and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dis sections. Compared to younger patients with FMD, patients >_65 years old had more often multifocal FMD, lower estimated glomerular filtration rate and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection, and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD di agnosis, male gender, stroke, and multivessel FMD. The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneur ysms and dissections, paving the way for targeted screening, management, and follow-up of FMD.

fibromuscular dysplasia ; dissection ; aneurysm ; renovascular hypertension ; stroke

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nije evidentirano

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nije evidentirano

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Podaci o izdanju

117

2021.

950-959

objavljeno

0008-6363

1755-3245

10.1093/cvr/cvaa102

Povezanost rada

Kliničke medicinske znanosti

Poveznice
Indeksiranost