engleski

Comparison of undiluted and diluted fibrinogen in concentration area between 4,5 and 7,0 g/L

BACKGROUND-AIM. The main objective of our work is to describe the epidemiological, clinical and especially biochemical profiles ofmonoclonal gammopathies in the Souss-Massa region in southern Morocco over a period of more than 10 years.METHODS- This is a retrospective study, we have exploited the records of patients diagnosed with monoclonal gammopathy atthis center over a period of 10 years, between 2010 and 2020. RESULTS. 117 patients were included in the study with a strong male predominance, 76 (65%) patients were male and 41 (35%)were female, with a male/female sex ratio of 1.85. The mean age± SD of our population was 61.44±14.54. monoclonalgammopathies in patients under 40 years of age represents a 6.8% of all gammopathies. The main symptoms ofmonoclonal gammopathy were as follows, bone pain in 66.6% (n=78), alteration of the general state with a rate of47.8% (n=56), bone marrow compression syndrome12.8% (n= 15). anemia in 70.9% (n=83), renal failure in 40.17%(n=47) and hypercalcemia in 23.9% (n=28). In our study the following diagnoses were retained, multiple myeloma82.05% (n=96), solitary plasmacytoma 8.5% (n=10), monoclonal gammapathies of undetermined significance 2. 60%(n=3), three cases of lymphoma 2.56% (n=3), two cases of plasma cell leukemia 1.7% (n=2) with a mean age of 64years, two cases of Waldenström disease 1.7% (n=2) and one case of chronic lymphocytic leukemia. Also, the isotypedistribution was as follows: IgG kappa 33.73% (n=28), IgG Lambda 21.68% (n=18), IgA Kappa 12.05% (n=10), IgALambda 7.22% (n=6), IgM kappa 3.61% (n=3) and IgD Lambda 2.41% (n=2). The biclonal peak was found in two caseswith a percentage of 2.41%. CONCLUSIONS. A prospective study associated with an etiological study of the cases of monoclonal gammopathies is necessary, especially since our region is an agricultural region.

fibrinogen ; concentration area

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