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Pregled bibliografske jedinice broj: 1191491

Targeting Microenvironment of Melanoma and Head and Neck Cancers in Photodynamic Therapy


Ratkaj, Ivana; Mušković, Martina; Malatesti, Nela
Targeting Microenvironment of Melanoma and Head and Neck Cancers in Photodynamic Therapy // Current medicinal chemistry, 29 (2022), 18; 3261-3299 doi:10.2174/0929867328666210709113032 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1191491 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Targeting Microenvironment of Melanoma and Head and Neck Cancers in Photodynamic Therapy

Autori
Ratkaj, Ivana ; Mušković, Martina ; Malatesti, Nela

Izvornik
Current medicinal chemistry (0929-8673) 29 (2022), 18; 3261-3299

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Photodynamic therapy ; Photosensitisers ; Tumour microenvironment ; Hypoxia ; Melanoma ; Head and neck cancer

Sažetak
Background: Photodynamic therapy (PDT), in comparison to other skin cancers, is still far less effective for melanoma, due to the strong absorbance and the role of melanin in cytoprotection. The tumour microenvironment (TME) has a significant role in tumour progression, and the hypoxic TME is one of the main reasons for melanoma progression to metastasis and its resistance to PDT. Hypoxia is also a feature of solid tumours in the head and neck region that indicates negative prognosis. Objective: The aim of this study was to individuate and describe systematically the main strategies in targeting the TME, especially hypoxia, in PDT against melanoma and head and neck cancers (HNC), and assess the current success in their application. Methods: PubMed was used for searching, in MEDLINE and other databases, for the most recent publications on PDT against melanoma and HNC in combination with the TME targeting and hypoxia. Results: In PDT for melanoma and HNC, it is very important to control hypoxia levels, and amongst the different approaches, oxygen self-supply systems are often applied. Vascular targeting is promising, but to improve it, optimal drug-light interval, and formulation to increase the accumulation of the photosensitiser in the tumour vasculature, have to be established. On the other side, the use of angiogenesis inhibitors, such as those interfering with VEGF signalling, is somewhat less successful than expected and needs to be further investigated. Conclusion: The combination of PDT with immunotherapy by using multifunctional nanoparticles continues to develop and seems to be the most promising for achieving a complete and lasting antitumour effect.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
NadSve-Sveučilište u Rijeci-uniri-prirod-18-173 - Priprema lipidnih konjugata piridilporfirina, njihova karakterizacija i fotodinamička aktivnost (Malatesti, Nela, NadSve - UNIRI projekti 2018) ( POIROT)

Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Martina Mušković (autor)

Avatar Url Nela Malatesti (autor)

Avatar Url Ivana Ratkaj (autor)

Poveznice na cjeloviti tekst rada:

doi www.eurekaselect.com

Citiraj ovu publikaciju:

Ratkaj, Ivana; Mušković, Martina; Malatesti, Nela
Targeting Microenvironment of Melanoma and Head and Neck Cancers in Photodynamic Therapy // Current medicinal chemistry, 29 (2022), 18; 3261-3299 doi:10.2174/0929867328666210709113032 (međunarodna recenzija, članak, znanstveni)
Ratkaj, I., Mušković, M. & Malatesti, N. (2022) Targeting Microenvironment of Melanoma and Head and Neck Cancers in Photodynamic Therapy. Current medicinal chemistry, 29 (18), 3261-3299 doi:10.2174/0929867328666210709113032.
@article{article, author = {Ratkaj, Ivana and Mu\v{s}kovi\'{c}, Martina and Malatesti, Nela}, year = {2022}, pages = {3261-3299}, DOI = {10.2174/0929867328666210709113032}, keywords = {Photodynamic therapy, Photosensitisers, Tumour microenvironment, Hypoxia, Melanoma, Head and neck cancer}, journal = {Current medicinal chemistry}, doi = {10.2174/0929867328666210709113032}, volume = {29}, number = {18}, issn = {0929-8673}, title = {Targeting Microenvironment of Melanoma and Head and Neck Cancers in Photodynamic Therapy}, keyword = {Photodynamic therapy, Photosensitisers, Tumour microenvironment, Hypoxia, Melanoma, Head and neck cancer} }
@article{article, author = {Ratkaj, Ivana and Mu\v{s}kovi\'{c}, Martina and Malatesti, Nela}, year = {2022}, pages = {3261-3299}, DOI = {10.2174/0929867328666210709113032}, keywords = {Photodynamic therapy, Photosensitisers, Tumour microenvironment, Hypoxia, Melanoma, Head and neck cancer}, journal = {Current medicinal chemistry}, doi = {10.2174/0929867328666210709113032}, volume = {29}, number = {18}, issn = {0929-8673}, title = {Targeting Microenvironment of Melanoma and Head and Neck Cancers in Photodynamic Therapy}, keyword = {Photodynamic therapy, Photosensitisers, Tumour microenvironment, Hypoxia, Melanoma, Head and neck cancer} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • BIOSIS Previews (Biological Abstracts)
  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)


Citati:





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