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Pregled bibliografske jedinice broj: 119129

Combination of ifosfamide, methotrexate, and etoposide (IMVP) as a salvage therapy for relapsed and refractory aggressive non-Hodgkin lymphoma: retrospective study.


Aurer, Igor; Duraković, Nadira; Radman, Ivo; Nemet, Damir; Zupančić-Šalek, Silva; Kovačević-Metelko, Jasminka; Bogdanić, Vinko; Sertić, Dubravka; Mrsić, Mirando; Mikulić, Mirta; Labar, Boris
Combination of ifosfamide, methotrexate, and etoposide (IMVP) as a salvage therapy for relapsed and refractory aggressive non-Hodgkin lymphoma: retrospective study. // Croatian medical journal, 43 (2002), 5; 550-554 (međunarodna recenzija, članak, znanstveni)


Naslov
Combination of ifosfamide, methotrexate, and etoposide (IMVP) as a salvage therapy for relapsed and refractory aggressive non-Hodgkin lymphoma: retrospective study.

Autori
Aurer, Igor ; Duraković, Nadira ; Radman, Ivo ; Nemet, Damir ; Zupančić-Šalek, Silva ; Kovačević-Metelko, Jasminka ; Bogdanić, Vinko ; Sertić, Dubravka ; Mrsić, Mirando ; Mikulić, Mirta ; Labar, Boris

Izvornik
Croatian medical journal (0353-9504) 43 (2002), 5; 550-554

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Lymphoma; Non-Hodgkin

Sažetak
AIM: There are contradictory reports on the outcomes of IMVP (ifosfamide, methotrexate, and etoposide) treatment in patients with aggressive non-Hodgkin s lymphomas. Our aim was to evaluate retrospectively the results of this treatment in our institution. METHODS: Twenty eight patients with refractory or relapsed aggressive non-Hodgkin s lymphomas received IMVP between April 1997 and June 2001. Median follow-up of the survivors was 24 months. There were 15 women and 13 men, aged 15-68 years. Twelve patients were refractory to primary treatment. The number of previous treatment lines varied between one and five. The overall response rate to IMVP treatment was 39%, with 6 patients achieving complete and 5 partial response/remission. Eleven patients received a subsequent hematopoietic stem cell transplant after IMVP therapy. RESULTS: Median duration of the survival for all patients was 6 months, and the response duration for responders 6 months. Nine patients had grade 3 hematologic toxicity or higher, 5 developed significant infectious complications, and one developed the tumor lysis syndrome. There was one treatment-related death due to infection. The patients with a low or low-intermediate international prognostic index at the start of IMVP had a significantly better survival and progression-free survival rates than those with high or high-intermediate score. Seven patients with hematopoietic stem cell transplant were alive in December 2001. CONCLUSION: IMVP is an active regimen with acceptable level of toxicity in patients with relapsed or refractory aggressive non-Hodgkin s lymphoma. However, outcomes of this treatment are unsatisfactory and better treatment is still needed. CAS Registry/EC Number

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Farmacija

Citiraj ovu publikaciju

Aurer, Igor; Duraković, Nadira; Radman, Ivo; Nemet, Damir; Zupančić-Šalek, Silva; Kovačević-Metelko, Jasminka; Bogdanić, Vinko; Sertić, Dubravka; Mrsić, Mirando; Mikulić, Mirta; Labar, Boris
Combination of ifosfamide, methotrexate, and etoposide (IMVP) as a salvage therapy for relapsed and refractory aggressive non-Hodgkin lymphoma: retrospective study. // Croatian medical journal, 43 (2002), 5; 550-554 (međunarodna recenzija, članak, znanstveni)
Aurer, I., Duraković, N., Radman, I., Nemet, D., Zupančić-Šalek, S., Kovačević-Metelko, J., Bogdanić, V., Sertić, D., Mrsić, M., Mikulić, M. & Labar, B. (2002) Combination of ifosfamide, methotrexate, and etoposide (IMVP) as a salvage therapy for relapsed and refractory aggressive non-Hodgkin lymphoma: retrospective study.. Croatian medical journal, 43 (5), 550-554.
@article{article, year = {2002}, pages = {550-554}, keywords = {Lymphoma, Non-Hodgkin}, journal = {Croatian medical journal}, volume = {43}, number = {5}, issn = {0353-9504}, title = {Combination of ifosfamide, methotrexate, and etoposide and \#40;IMVP and \#41; as a salvage therapy for relapsed and refractory aggressive non-Hodgkin lymphoma: retrospective study.}, keyword = {Lymphoma, Non-Hodgkin} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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