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Pregled bibliografske jedinice broj: 1190722

Association of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors with disease severity in COVID-19 patients: A pilot study


Lapić, Ivana; Radić Antolic, Margareta; Horvat, Ivana; Premužić, Vedran; Palić, Jozefina; Rogić, Dunja; Zadro, Renata
Association of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors with disease severity in COVID-19 patients: A pilot study // Journal of medical virology (2022) doi:10.1002/jmv.27774 (znanstveni, online first)


CROSBI ID: 1190722 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors with disease severity in COVID-19 patients: A pilot study

Autori
Lapić, Ivana ; Radić Antolic, Margareta ; Horvat, Ivana ; Premužić, Vedran ; Palić, Jozefina ; Rogić, Dunja ; Zadro, Renata

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Journal of medical virology (2022)

Status rada
Online first

Ključne riječi
COVID-19 ; genetic polymorphisms ; thrombosis ; cardiovascular risk

Sažetak
Introduction The present study aimed to assess the association of 16 polymorphisms in genes encoding prothrombotic and cardiovascular risk factors with COVID-19 disease severity: FV G1691A, FV H1299R, FII G20210A, MTHFR C677T, MTHFR A1298, factor XIII V34L, PAI-1 4G/5G, EPCR haploytpes (A1/A2/A3), eNOS -786 T>C, eNOS G894T, LTA C804A, ACE I/D, ITGB3 PIA1/A2, ITGA2B Baka/b, β-Fbg -455 G>A and ApoB R3500Q. Methods The study included 30 patients with severe COVID- 19 and 49 non-severe COVID-19 patients. All studied polymorphisms except ITGA2B Baka/b were determined using multilocus genotyping assays CVD StripAssays (ViennaLab Diagnostics, Vienna, Austria), while ITGA2B was genotyped using a real- time PCR method based on TaqMan technology. Results Higher frequency of carriers of at least one ITGB3 PIA2 allele was found in severe COVID-19 patients (P=0.009). The distribution of genotypes was significantly different for ß- Fbg -455G>A (P=0.042), with the only three homozygous AA genotypes found among severe COVID-19 patients. The association with an increased risk for severe COVID-19 was found for ITGB3, with carriers of at least one ITGB3 PIA2 allele having a 3.5-fold greater risk of severe COVID-19 (P=0.011). Genotype distribution differences were obtained for the combinations of FV H1299R and FXIII V34L (P=0.026), ITGB3 PIA1/A2 and ITGA2B Baka/b (P=0.024), and ACE I/D and PAI-1 4G/5G (P=0.046). Conclusion ITGB3 polymorphism emerged as an independent risk factor for severe COVID-19 and homozygosity for ß- Fbg -455 G>A mutation could contribute to disease severity. The combined effect of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors, could further contribute to disease severity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Specijalna bolnica Sv. Katarina

Poveznice na cjeloviti tekst rada:

doi onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Lapić, Ivana; Radić Antolic, Margareta; Horvat, Ivana; Premužić, Vedran; Palić, Jozefina; Rogić, Dunja; Zadro, Renata
Association of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors with disease severity in COVID-19 patients: A pilot study // Journal of medical virology (2022) doi:10.1002/jmv.27774 (znanstveni, online first)
Lapić, I., Radić Antolic, M., Horvat, I., Premužić, V., Palić, J., Rogić, D. & Zadro, R. (2022) Association of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors with disease severity in COVID-19 patients: A pilot study. Prihvaćen za objavljivanje u Journal of medical virology. [Preprint] doi:10.1002/jmv.27774.
@unknown{unknown, author = {Lapi\'{c}, Ivana and Radi\'{c} Antolic, Margareta and Horvat, Ivana and Premu\v{z}i\'{c}, Vedran and Pali\'{c}, Jozefina and Rogi\'{c}, Dunja and Zadro, Renata}, year = {2022}, DOI = {10.1002/jmv.27774}, keywords = {COVID-19, genetic polymorphisms, thrombosis, cardiovascular risk}, journal = {Journal of medical virology}, doi = {10.1002/jmv.27774}, title = {Association of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors with disease severity in COVID-19 patients: A pilot study}, keyword = {COVID-19, genetic polymorphisms, thrombosis, cardiovascular risk} }
@unknown{unknown, author = {Lapi\'{c}, Ivana and Radi\'{c} Antolic, Margareta and Horvat, Ivana and Premu\v{z}i\'{c}, Vedran and Pali\'{c}, Jozefina and Rogi\'{c}, Dunja and Zadro, Renata}, year = {2022}, DOI = {10.1002/jmv.27774}, keywords = {COVID-19, genetic polymorphisms, thrombosis, cardiovascular risk}, journal = {Journal of medical virology}, doi = {10.1002/jmv.27774}, title = {Association of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors with disease severity in COVID-19 patients: A pilot study}, keyword = {COVID-19, genetic polymorphisms, thrombosis, cardiovascular risk} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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