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Sorption potential of different forms of TiO2 for the removal of two anticancer drugs from water

Anticancer drugs pose a potential risk to the environment due to their significant consumption and biological effect even at low concentrations. They can leach into soils and sediments, wastewater, and eventually into drinking water supplies. Many conventional technologies with more effective advanced oxidation processes such as photocatalysis are being extensively studied to find an economical and environmentally friendly solution for the removal of impurities from wastewater as the main source of these pharmaceuticals. Since it is impossible to treat water by photocatalysis if there is no sorption of a contaminant on the photocatalyst, this work investigated the amount of imatinib and crizotinib sorbed from an aqueous medium to different forms of photocatalyst. In addition, based on the sorption affinity studied, the applicability of sorption as a simpler and less costly process was tested in general as a potential route to remove imatinib and crizotinib from water. Their sorption possibility was investigated by determining the maximum of sorption, the influence of pH, ionic strength, temperature, and sorbent dosage in form of the suspension and immobilized on the fiberglass mesh with only TiO2 and in combination with TiO2/carbon nanotubes. The sorption isotherm data fitted well the linear, Freundlich, and Langmuir model for both pharmaceuticals. An increasing trend of sorption coefficients Kd was observed in the pH range of 5–9 with CRZ, showing higher sorption affinity to all TiO2 forms, which was supported by KF values higher than 116 (µg/g) (mL/µg)1/n. The results also show a positive correlation between Kd and temperature as well as sorbent dosage for both pharmaceuticals, while CRZ sorbed less at higher salt concentration. The kinetic data were best described with a pseudo- second-order model (R 2 > 0.995).

sorption process ; imatinib ; crizotinib ; TiO2 suspension ; TiO2 immobilized onto glass mesh ; TiO2/carbon nanotubes

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