engleski

Vitamin D deficiency in young adults and the question of the need for early replacement for the primary prevention of osteoporosis

Introduction: Low concentrations of vitamin D are associated with decreased calcium absorption, negative calcium balance, and compensatory growth of parathyroid hormone, resulting in excessive bone resorption. The first step in preventing osteoporosis is to ensure a proper diet, especially calcium and vitamin D intake. Aim of the study: The aim of this study was to determine the concentration of 25-hydroxyvitamin D3 (25-OH-D3) in Eastern Croatia in subjects aged 18 to 25 years at the end of winter and to examine whether there is a difference according to gender and compare the results with reference values. Subjects and methods The study was conducted on a sample of 59 subjects, with an average age of 23 years, of which 27 were men (45.8%) and 32 women (54.2%). Blood was drawn and centrifuged at 3.000 rpm for 10 minutes. After centrifugation, serum was collected, and the sample was analyzed by liquid chromatography combined with mass spectrometry (LC-MS/MS). Results: The mean concentration of 25-OH-D3 was 16.36 ng/ml (SD 5.68 ; range 4.90 to 28.60). Men had a statistically significant higher concentration compared to women (18.96 vs. 14.16 ng/ml, p 0.01). The concentration was lower than the reference value (20 to 100 ng/ml). Only 28.8% of subjects (44.4% men and 15.6% women) had values greater than 20 ng/ml. Conclusion: As many as 71.2% of young adults had vitamin D deficiency at the end of the winter period. Women had statistically significant lower concentrations. The observed deficit indicates the need to determine the optimal intake of 25-OH-D3 for the purpose of osteoporosis prevention. It is necessary to conduct research on a larger number of examinees over a longer period with monitoring of outcomes.

calcifediol ; vitamin D deficiency ; young adults ; liquid chromatography-mass spectrometry ; osteoporosis

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