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Pregled bibliografske jedinice broj: 119022

P21WAF1/CIP1 is more effective than p53 in growth suppression of mouse renal carcinoma cell line Renca in vitro and in vivo


Kralj, Marijeta; Pavelić, Jasminka
p21WAF1/CIP1 is more effective than p53 in growth suppression of mouse renal carcinoma cell line Renca in vitro and in vivo // Journal of cancer research and clinical oncology, 129 (2003), 8; 463-471 (međunarodna recenzija, članak, znanstveni)


Naslov
P21WAF1/CIP1 is more effective than p53 in growth suppression of mouse renal carcinoma cell line Renca in vitro and in vivo

Autori
Kralj, Marijeta ; Pavelić, Jasminka

Izvornik
Journal of cancer research and clinical oncology (0171-5216) 129 (2003), 8; 463-471

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
P53; p21WAF1/CIP1; gene therapy; apoptosis; Renca cells

Sažetak
Althouhg there are many controversial reports about the effect of p53 and p21 overexpression in different human tumor cells. the p53 gene is shown to be more effective candidate for cancer gene therapy because of its pronounced ability to induce apoptosis. In the present study, we present the effect of p53 and p21 overexpression on mouse renal carcinoma cells in vitro and in vivo. The data suggest that p21 is more potent growth suppressor than p53 of mouse tumor cells Renca. The divergent responses of tumor cells top21 overexpression could be due to various networks that differ between species.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0098092

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Index Medicus