engleski

Peptic ulcer bleeding in elderly patients – what has changed over a ten year period

Aims To demonstrate differences in epidemiological, clinical, endoscopic characteristics and outcome in elderly patients(> 80 years) with peptic ulcer bleeding(PUB) between 2008 and 2018. Methods From January 2008 till December 2008 a total of 34 elderly patients referred to our emergency department due PUB. From January 2018 till December 2018 a total of 45 elderly patients referred to our emergency department due PUB. Both group of patients were screened and enrolled in this study. Results A significantly higher nubmer of elderly patients was found in our study relative to the proportion of older people in the population(3, 3 vrs 24.8% and 4.6 vs 35.2%)(p < 0.001). There was no statistically significant difference in PUB incidence in elderly patients between 2008 and 2018(9.7/100, 000 vs 12.9/100, 000). In 2018 most patients had moderately severe to severe comorbidities(88.9% vs 41.2%, p < 0.001). Initial hemostasis was performed in significantly more patients in 2018 than in 2008(66.7 vs 44.1%, p < 0.04). There was no difference in the recurrence of bleeding(9.1% vs 6.7%) and 30-day mortality(8.8% vs. 6.7%) between year 2018 and 2008. In 2008 significantly more patients was transferred to Department of surgery(11.8% vs 0%, p 0.02). In 2018 patients were longer hospitalized(8 vs. 6.5 days, p < 0.01). In the year 2018 and 2008 the majority of patients with PUB were taking agents that attenuate cytoprotective function of stomach and duodenal mucosa(66.5 vs 55.1%). In 2018 higher number of patients had anticoagulant and antiplatelet therapy compared to 2008(44.3 vs 14.7%, p < 0.01). Conclusions A significantly higher nubmer of elderly patients was found in our study relative to the proportion of older people in the population. We registreted increase comorbidities, duration of hospitalisation, use of agentns that attenuate cytoprotective function of stomach and duodenal mucosa, use of antiplatelet and anticoagulant therapy for the last 10 years in elderly patients.

peptic ulcer ; bleeding ; elderly

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