engleski

Vitamin D supplementation in patients with chronic urticaria, atopic dermatitis, or contact dermatitis – how did it affect clinical improvement?

Introduction: As for the vitamin D levels in patients with chronic urticaria (CU) and atopic dermatitis (AD), numerous studies on CU patients have shown their significantly lower serum levels of 25-(OH)-D than in the control group. Some authors showed a negative association between the severity of CU and the serum 25-(OH)-D levels. So, we decided to examine the values of serum vitamin D in patients with CU, AD, and CD (ICD, ACD) and the effects of its supplementation in the patients with low vitamin D values. Aim: Evaluating serum vitamin D values in patients with inflammatory skin diseases, comparing them on the basis of other parameters (age, gender/sex, residential areas, total serum IgE), and establishing if vitamin D supplementation would affect the improvement of the clinical picture of the disease. Patients and Methods: A total of 157 patients participated in this prospective study: 55 with CU, 51 patients with AD, and 51 with contact dermatitis (CD): 38 with irritant CD (ICD) and 13 with allergic CD (ACD). In all patients, the values of serum vitamin D were determined by chemiluminescence microparticle immunoassay (CMIA) and compared by diagnosis, age, sex, living environment, values of total IgE. In patients with reduced values of vitamin D, its supplementation for 3 months was recommended, after which the second evaluation of D vitamin values and disease status were determined and compared with an untreated/unsupplemented group with normal vitamin D values. Results: Vitamin D deficiency was often observed in patients with CU, AD and CD, most frequently in the ICD group, and least frequently in the ACD group. No significant differences were found in terms of age, gender or living environment, nor did they correlate with total IgE. In the subjects supplemented with vitamin D, their levels increased significantly and, after its supplementation, improvement of the clinical condition was more common than in the untreated group ; however, the differences were not statistically significant (69.8 vs 58.1 ; p=0.428). Conclusion Although the serum vitamin D levels of the groups did not differ significantly, the supplementation of vitamin D in patients with prominent vitamin D deficiency may be useful and crucial for some patients and their prognosis of the disease.

urticaria ; atopic dermatitis ; contact dermatitis ; vitamin D deficiency ; skin inflammatory diseases

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