miRNA-guided reprogramming of glucose and glutamine metabolism and its impact on cell adhesion/migration during solid tumor progression (CROSBI ID 307992)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Quirico, Lorena ; Orso, Francesca ; Cucinelli, Stefania ; Paradžik, Mladen ; Natalini, Dora ; Centonze, Giorgia ; Dalmasso, Alberto ; La Vecchia, Sofia ; Coco, Martina ; Audrito, Valentina ; Riganti, Chiara ; Defilippi, Paola ; Taverna, Daniela
engleski
miRNA-guided reprogramming of glucose and glutamine metabolism and its impact on cell adhesion/migration during solid tumor progression
MicroRNAs (miRNAs) are small, non-coding RNAs about 22 nucleotides in length that regulate the expression of target genes post-transcriptionally, and are highly involved in cancer progression. They are able to impact a variety of cell processes such as proliferation, apoptosis and differentiation and can consequently control tumor initiation, tumor progression and metastasis formation. miRNAs can regulate, at the same time, metabolic gene expression which, in turn, influences relevant traits of malignancy such as cell adhesion, migration and invasion. Since the interaction between metabolism and adhesion or cell movement has not, to date, been well understood, in this review, we will specifically focus on miRNA alterations that can interfere with some metabolic processes leading to the modulation of cancer cell movement. In addition, we will analyze the signaling pathways connecting metabolism and adhesion/migration, alterations that often affect cancer cell dissemination and metastasis formation.
miRNAs ; Metabolism ; Cancer ; Metastasis ; Adhesion
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Podaci o izdanju
79
2022.
216
16
objavljeno
1420-682X
1420-9071
10.1007/s00018-022-04228-y
Povezanost rada
Biologija, Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti