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Pregled bibliografske jedinice broj: 1187736

Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance


Erin, Nuray; Grahovac, Jelena; Brozovic, Anamaria; Efferth, Thomas
Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance // Drug resistance updates, 53 (2020), 100715, 22 doi:10.1016/j.drup.2020.100715. (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 1187736 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance

Autori
Erin, Nuray ; Grahovac, Jelena ; Brozovic, Anamaria ; Efferth, Thomas

Izvornik
Drug resistance updates (1368-7646) 53 (2020); 100715, 22

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Chemotherapy ; Hypoxia ; Inflammation ; Microenvironment ; Multidrug resistance ; Small molecules ; Targeted therapy.

Sažetak
It is well established that multifactorial drug resistance hinders successful cancer treatment. Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial-mesenchymal transition (EMT) and multidrug resistance (MDR). TME-induced factors secreted by cancer cells and cancer-associated fibroblasts (CAFs) create an inflammatory microenvironment by recruiting immune cells. CD11b+/Gr-1+ myeloid-derived suppressor cells (MDSCs) and inflammatory tumor associated macrophages (TAMs) are main immune cell types which further enhance chronic inflammation. Chronic inflammation nurtures tumor-initiating/cancer stem-like cells (CSCs), induces both EMT and MDR leading to tumor relapses. Pro-thrombotic microenvironment created by inflammatory cytokines and chemokines from TAMs, MDSCs and CAFs is also involved in EMT and MDR. MDSCs are the most common mediators of immunosuppression and are also involved in resistance to targeted therapies, e.g. BRAF inhibitors and oncolytic viruses-based therapies. Expansion of both cancer and stroma cells causes hypoxia by hypoxia-inducible transcription factors (e.g. HIF-1α) resulting in drug resistance. TME factors induce the expression of transcriptional EMT factors, MDR and metabolic adaptation of cancer cells. Promoters of several ATP-binding cassette (ABC) transporter genes contain binding sites for canonical EMT transcription factors, e.g. ZEB, TWIST and SNAIL. Changes in glycolysis, oxidative phosphorylation and autophagy during EMT also promote MDR. Conclusively, EMT signaling simultaneously increases MDR. Owing to the multifactorial nature of MDR, targeting one mechanism seems to be non-sufficient to overcome resistance. Targeting inflammatory processes by immune modulatory compounds such as mTOR inhibitors, demethylating agents, low-dosed histone deacetylase inhibitors may decrease MDR. Targeting EMT and metabolic adaptation by small molecular inhibitors might also reverse MDR. In this review, we summarize evidence for TME components as causative factors of EMT and anticancer drug resistance.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-1036 - Određivanje ključnih molekula epitelno-mezenhimalne tranzicije kao mogućih ciljeva za terapiju raka jajnika (DEvOuT) (Brozović, Anamaria, HRZZ - 2016-06) ( POIROT)

Profili:

Avatar Url Anamaria Brozović (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Erin, Nuray; Grahovac, Jelena; Brozovic, Anamaria; Efferth, Thomas
Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance // Drug resistance updates, 53 (2020), 100715, 22 doi:10.1016/j.drup.2020.100715. (međunarodna recenzija, pregledni rad, znanstveni)
Erin, N., Grahovac, J., Brozovic, A. & Efferth, T. (2020) Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance. Drug resistance updates, 53, 100715, 22 doi:10.1016/j.drup.2020.100715..
@article{article, author = {Erin, Nuray and Grahovac, Jelena and Brozovic, Anamaria and Efferth, Thomas}, year = {2020}, pages = {22}, DOI = {10.1016/j.drup.2020.100715.}, chapter = {100715}, keywords = {Chemotherapy, Hypoxia, Inflammation, Microenvironment, Multidrug resistance, Small molecules, Targeted therapy.}, journal = {Drug resistance updates}, doi = {10.1016/j.drup.2020.100715.}, volume = {53}, issn = {1368-7646}, title = {Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance}, keyword = {Chemotherapy, Hypoxia, Inflammation, Microenvironment, Multidrug resistance, Small molecules, Targeted therapy.}, chapternumber = {100715} }
@article{article, author = {Erin, Nuray and Grahovac, Jelena and Brozovic, Anamaria and Efferth, Thomas}, year = {2020}, pages = {22}, DOI = {10.1016/j.drup.2020.100715.}, chapter = {100715}, keywords = {Chemotherapy, Hypoxia, Inflammation, Microenvironment, Multidrug resistance, Small molecules, Targeted therapy.}, journal = {Drug resistance updates}, doi = {10.1016/j.drup.2020.100715.}, volume = {53}, issn = {1368-7646}, title = {Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance}, keyword = {Chemotherapy, Hypoxia, Inflammation, Microenvironment, Multidrug resistance, Small molecules, Targeted therapy.}, chapternumber = {100715} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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