Ferritin light and heavy chain expression in the liver and kidneys of Wistar rats: aging, sex differences, and impact of gonadectomy (CROSBI ID 307927)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Pavić Vulinović, Mirela ; Turčić, Petra ; Micek, Vedran ; Ljubojević, Marija
engleski
Ferritin light and heavy chain expression in the liver and kidneys of Wistar rats: aging, sex differences, and impact of gonadectomy
Ferritin is the main intracellular storage of iron. Animal studies show that female liver and kidney express more ferritin and accumulate more iron than male. However, no study so far has investigated sex and age differences in light (FtL) and heavy (FtH) ferritin chain expression. To address this, we relied on specific antibodies and immunochemical methods to analyse the expression of both ferritin chains in the liver and kidney of 3-month and 2- year-old male and female Wistar rats. To see how sex hormones may affect expression we also studied adult animals gonadectomised at the age of 10 weeks. FtL and FtH were more expressed in both organs of female rats, while gonadectomy increased the expression in males and decreased it in females, which suggests that it is stimulated by female and inhibited by male steroid hormones. Normal kidney ferritin distribution and change with aging warrant more attention in studies of (patho) physiological and toxicological processes.
ferritin nanocage ; hepatocytes ; immunofluorescence ; intercalated cells, iron metabolism ; macula densa ; nephron ; steroid hormones ; western blot
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Podaci o izdanju
73
2022.
48-61
objavljeno
0004-1254
1848-6312
10.2478/aiht-2022-73-3621
Povezanost rada
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Interdisciplinarne biotehničke znanosti, Temeljne medicinske znanosti, Veterinarska medicina