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Pregled bibliografske jedinice broj: 1187662

Association between BCL2, BCL2 E17, MCL1 and BAX Protein Expression, Bone Marrow Microenvironment Histological Features, Clinical Presentation, Therapeutic Outcome, and the Overall Survival in Newly Diagnosed Multiple Myeloma


Škrtić, Anita; Jaksić, Ozren; Ostojić, Slobodanka; Antica, Mariastefania; Crnković, Petra; Skelin, Josipa; Jurenec, Silvana; Habijanec, Borna; Radić Kristo, Delfa
Association between BCL2, BCL2 E17, MCL1 and BAX Protein Expression, Bone Marrow Microenvironment Histological Features, Clinical Presentation, Therapeutic Outcome, and the Overall Survival in Newly Diagnosed Multiple Myeloma // Blood, 138 (2021), 1; 4716-4717 (međunarodna recenzija, ostalo, znanstveni)


CROSBI ID: 1187662 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association between BCL2, BCL2 E17, MCL1 and BAX Protein Expression, Bone Marrow Microenvironment Histological Features, Clinical Presentation, Therapeutic Outcome, and the Overall Survival in Newly Diagnosed Multiple Myeloma

Autori
Škrtić, Anita ; Jaksić, Ozren ; Ostojić, Slobodanka ; Antica, Mariastefania ; Crnković, Petra ; Skelin, Josipa ; Jurenec, Silvana ; Habijanec, Borna ; Radić Kristo, Delfa

Izvornik
Blood (0006-4971) 138 (2021), 1; 4716-4717

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, ostalo, znanstveni

Ključne riječi
Multiple Myeloma ; BCL2 ; BCL2 E17 ; MCL1 ; BAX

Sažetak
We evaluated the correlation between immunohistochemical BCL2, BCL2 E17, MCL1 (Bcl2- related protein family) and BAX (effector proapoptotic protein) expression and intensity of staining in plasma cells (PC) in MM patients (pts) who were eligible for autologous stem cell transplantation (ASCT) with DD4, CD8, and FOXP3 positive Tregs lymphocytes in bone marrow (BM) microenvironment, morphologic features of PC, clinical parameters, and outcomes. Immunohistochemical staining of BCL2, BCL2 E17, MCL1, BAX, CD4, CD8, FOXP3 and Ki67 was performed in BM biopsy of 36 newly diagnosed MM patients who were eligible for ASCT between 2012-2017 at University Hospital Merkur. Pearson's and Spearmans's coefficients of correlation, t-tests, one-way independent sample ANOVAs, mixed ANOVAs, moderation analyses, chi-square tests of independence and Cox's proportional hazards were used to analyze the data.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2020-02-2431 - Obnova timusa za preciznu medicinu u liječenju tumora i leukemija (THYMINNOVA) (Antica, Mariastefania, HRZZ - 2020-02) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

doi.org

Citiraj ovu publikaciju:

Škrtić, Anita; Jaksić, Ozren; Ostojić, Slobodanka; Antica, Mariastefania; Crnković, Petra; Skelin, Josipa; Jurenec, Silvana; Habijanec, Borna; Radić Kristo, Delfa
Association between BCL2, BCL2 E17, MCL1 and BAX Protein Expression, Bone Marrow Microenvironment Histological Features, Clinical Presentation, Therapeutic Outcome, and the Overall Survival in Newly Diagnosed Multiple Myeloma // Blood, 138 (2021), 1; 4716-4717 (međunarodna recenzija, ostalo, znanstveni)
Škrtić, A., Jaksić, O., Ostojić, S., Antica, M., Crnković, P., Skelin, J., Jurenec, S., Habijanec, B. & Radić Kristo, D. (2021) Association between BCL2, BCL2 E17, MCL1 and BAX Protein Expression, Bone Marrow Microenvironment Histological Features, Clinical Presentation, Therapeutic Outcome, and the Overall Survival in Newly Diagnosed Multiple Myeloma. Blood, 138 (1), 4716-4717.
@article{article, author = {\v{S}krti\'{c}, Anita and Jaksi\'{c}, Ozren and Ostoji\'{c}, Slobodanka and Antica, Mariastefania and Crnkovi\'{c}, Petra and Skelin, Josipa and Jurenec, Silvana and Habijanec, Borna and Radi\'{c} Kristo, Delfa}, year = {2021}, pages = {4716-4717}, keywords = {Multiple Myeloma, BCL2, BCL2 E17, MCL1, BAX}, journal = {Blood}, volume = {138}, number = {1}, issn = {0006-4971}, title = {Association between BCL2, BCL2 E17, MCL1 and BAX Protein Expression, Bone Marrow Microenvironment Histological Features, Clinical Presentation, Therapeutic Outcome, and the Overall Survival in Newly Diagnosed Multiple Myeloma}, keyword = {Multiple Myeloma, BCL2, BCL2 E17, MCL1, BAX} }
@article{article, author = {\v{S}krti\'{c}, Anita and Jaksi\'{c}, Ozren and Ostoji\'{c}, Slobodanka and Antica, Mariastefania and Crnkovi\'{c}, Petra and Skelin, Josipa and Jurenec, Silvana and Habijanec, Borna and Radi\'{c} Kristo, Delfa}, year = {2021}, pages = {4716-4717}, keywords = {Multiple Myeloma, BCL2, BCL2 E17, MCL1, BAX}, journal = {Blood}, volume = {138}, number = {1}, issn = {0006-4971}, title = {Association between BCL2, BCL2 E17, MCL1 and BAX Protein Expression, Bone Marrow Microenvironment Histological Features, Clinical Presentation, Therapeutic Outcome, and the Overall Survival in Newly Diagnosed Multiple Myeloma}, keyword = {Multiple Myeloma, BCL2, BCL2 E17, MCL1, BAX} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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