engleski

Immunochemistry assays TRAb vs TSI in patients with thyroid disease

Thyrotoxicosis is a condition having multiple etiologies, manifestations, and potential therapies. It refers to a clinical state that results from inappropriately high thyroid hormone action in tissues generally due to inappropriately high tissue thyroid hormone levels. Appropriate treatment of thyrotoxicosis requires an accurate diagnosis which involves among other quantification of thyrotropin-receptor antibodies (TRAb) and/or antibodies with stimulating activity (TSI). The TSH receptor (TSHR) binds autoantibodies, TSI or thyroid blocking immunoglobulins (TBI) that in contrast to TSI inhibit stimulation of thyroid cells leading to hypothyroidism while TSI bind to TSHR and mimic TSH stimulation (hyperthyroidism). TSI includes determination of autoimmune etiology of thyrotoxicosis, conformation of Graves ophalmopathy (GO) or monitoring Graves disease, prediction of remission or relapse and prediction of hyperthyroidism in neonates.

thyrotoxicosis, thyrotropin receptor antibodies, antibodies with stimulating activity

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