Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial (CROSBI ID 307594)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

White, Harvey D ; Steg, Ph Gabriel ; Szarek, Michael ; Bhatt, Deepak L ; Bittner, Vera A ; Diaz, Rafael ; Edelberg, Jay M ; Erglis, Andrejs ; Goodman, Shaun G ; Hanotin, Corinne et al. Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial // European heart journal, 40 (2019), 33; 2801-2809. doi: 10.1093/eurheartj/ehz299

Podaci o odgovornosti

White, Harvey D ; Steg, Ph Gabriel ; Szarek, Michael ; Bhatt, Deepak L ; Bittner, Vera A ; Diaz, Rafael ; Edelberg, Jay M ; Erglis, Andrejs ; Goodman, Shaun G ; Hanotin, Corinne ; Harrington, Robert A ; Jukema, J Wouter ; Lopes, Renato D ; Mahaffey, Kenneth W ; Moryusef, Angele ; Pordy, Robert ; Roe, Matthew T ; Sritara, Piyamitr ; Tricoci, Pierluigi ; Zeiher, Andreas M ; Schwartz, Gregory G ; ODYSSEY OUTCOMES Investigators

engleski

Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial

Aims: The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous ; Type 2, related to oxygen supply/demand imbalance ; Type 3, fatal without ascertainment of cardiac biomarkers ; Type 4, related to percutaneous coronary intervention ; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL- C) reduction with statins and proprotein convertase subtilisin-kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results: Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77-0.95 ; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77-0.99 ; P = 0.032) and Type 2 (0.77, 0.61-0.97 ; P = 0.025), but not Type 4 MI. Conclusion: After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types

Alirocumab ; MI types ; Mortality ; Prevention

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

40 (33)

2019.

2801-2809

objavljeno

0195-668X

10.1093/eurheartj/ehz299

Povezanost rada

Kliničke medicinske znanosti

Poveznice
Indeksiranost