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Arteriolar reactivity to dilator agents and elevated PO2in Dahl S and renin congenic rats


Drenjančević-Perić, Ines; Greene, A. S.; Kunert, M.P.; Lombard J.H.
Arteriolar reactivity to dilator agents and elevated PO2in Dahl S and renin congenic rats // FASEB Journal
Washington DC, USA, 2003. str. 121-121 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Arteriolar reactivity to dilator agents and elevated PO2in Dahl S and renin congenic rats

Autori
Drenjančević-Perić, Ines ; Greene, A. S. ; Kunert, M.P. ; Lombard J.H.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FASEB Journal / - , 2003, 121-121

Skup
EXBO : Experimental Biologa Meeting

Mjesto i datum
Washington DC, USA, 18.-22.4.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hypertension; arterioal reactivity; dilatator agents

Sažetak
The renin-angiotensin system (RAS) plays an important role in maintaining normal vascular reactivity. Dahl salt-sensitive (Dahl S) rats exhibit low renin levels and impaired responses to vasodilator stimuli. Renin-congenic (RGRR) rats, derived by transfer of a region of chromosome 13 containing the renin gene from the Dahl salt-resistant strain onto the genetic background of the Dahl S strain, exhibit normal modulation of plasma renin activity. In the present study, age-matched male RGRR and Dahl S rats were fed low salt (LS) (0.4% NaCl) or high salt (HS) diet (4% NaCl) for 4 weeks with water ad libitum. The responses of third order arterioles of the in situ cremaster muscle to acetylcholine (ACh), sodium nitroprusside (SNP) and elevation of superfusate O2 concentration from 0% O2 to 21% O2 were assessed by video microscopy. ACh induced dilation was impaired in arterioles of Dahl S rats on HS diet, compared to controls on LS diet and RGRR rats on HS diet. In RGRR, transfer of the renin gene restored dilator responses to ACh in rats on either diet. SNP dilation was similar in Dahl S rats and RGRR rats, regardless of diet. HS diet augmented O2 induced constriction of arterioles of both Dahl S rats and RGRR rats. These data suggest that restoration of normal renin control mechanisms contribute to the recovery of vasodilator responses in RGRR rats, but do not impact constrictor responses to elevated PO2. (NIH #HL29587 and #HL-65289)

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0219281

Ustanove
Medicinski fakultet, Osijek

Profili:

Avatar Url Ines Drenjančević (autor)

Citiraj ovu publikaciju

Drenjančević-Perić, Ines; Greene, A. S.; Kunert, M.P.; Lombard J.H.
Arteriolar reactivity to dilator agents and elevated PO2in Dahl S and renin congenic rats // FASEB Journal
Washington DC, USA, 2003. str. 121-121 (poster, međunarodna recenzija, sažetak, znanstveni)
Drenjančević-Perić, I., Greene, A., Kunert, M. & Lombard J.H. (2003) Arteriolar reactivity to dilator agents and elevated PO2in Dahl S and renin congenic rats. U: FASEB Journal.
@article{article, year = {2003}, pages = {121-121}, keywords = {hypertension, arterioal reactivity, dilatator agents}, title = {Arteriolar reactivity to dilator agents and elevated PO2in Dahl S and renin congenic rats}, keyword = {hypertension, arterioal reactivity, dilatator agents}, publisherplace = {Washington DC, USA} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE