Immunization against SARS-CoV-2 using cytomegalovirus as a vaccine vector (CROSBI ID 716148)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Materljan Jelena, Šustić Marko, Cokarić Brdovčak Maja, Ružić Tina, Ravlić Sanda, Lang Balija Maja, Halassy Beata, Forčić Dubravko, Čičin-Šain Luka, Lisnić Berislav, Krmpotić Astrid, Jonjić Stipan
engleski
Immunization against SARS-CoV-2 using cytomegalovirus as a vaccine vector
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current worldwide COVID-19 pandemic, with over 200 million people infected so far. To combat the pandemic, several vaccines that elicit successful protective immune response have been developed and approved. Two main types of these vaccines include messenger RNA (mRNA) based technology and viral vectors. Although these vaccines proved to be very efficient, the longevity of protective immune response is still undefined. Cytomegaloviruses (CMVs) are βherpesviruses with great potential to be used as viral vectors. CMVs establish latency from which periodic reactivation occurs, boosting the specific immune response to viral antigens. Their key characteristic is the induction of a large pool of functional antigen-specific CD8⁺ T cells, which accumulate over time. We have constructed several murine CMV (MCMV) vaccine vectors expressing S (spike) and M (membrane) proteins of the SARS-CoV-2. Immunization with these vectors led to outstanding CD8⁺ T cell response and the generation of neutralizing antiviral antibodies. Importantly, not only immunization via systemic route but also via intranasal application of vectors, resulted in induction of protective immune response accompanied with induction of tissue resident memory CD8⁺ T cells in the lungs. Overall, our results demonstrate that herpesviruses are promising vaccine vectors against SARS-CoV-2 due to their capacity to induce exceptional and long-lasting antibody and cellular immune response.
murine CMV, SARS-CoV-2, vaccine vectors, immunization
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Podaci o prilogu
22-22.
2021.
objavljeno
Podaci o matičnoj publikaciji
2021 Annual Meeting Of The Croatian Immunological Society - Abstract book
Podaci o skupu
Annual meeting of the Croatian Immunological Society 2021
poster
23.09.2021-25.09.2021
Trogir, Hrvatska