C reactive protein to albumin ratio as prognostic marker in primary and secondary myelofibrosis (CROSBI ID 307313)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Lucijanic, Marko ; Galusic, Davor ; Krecak, Ivan ; Sedinic, Martina ; Soric, Ena ; Holik, Hrvoje ; Perisa, Vlatka ; Moric Peric, Martina ; Zekanovic, Ivan ; Stoos-Veic, Tajana ; Kusec, Rajko
engleski
C reactive protein to albumin ratio as prognostic marker in primary and secondary myelofibrosis
We retrospectively investigated C reactive protein to albumin ratio (CAR) in a cohort of 142 patients with myelofibrosis [101 primary (PMF) ; 41 secondary (SMF)] and compared it to hematological and clinical parameters. Among other associations, higher CAR was significantly associated with higher grade of bone marrow fibrosis, lower frequency of Calreticulin (CALR) mutations, presence of constitutional symptoms, massive splenomegaly, transfusion dependency, blast phase disease, lower hemoglobin, lower platelets, higher ferritin and higher lactate dehydrogenase (LDH) (p < .05 for all analyses). Higher CAR was able to predict inferior survival in PMF independently of DIPSS [hazard ratio (HR)¼2.17 ; p ¼ .015 for high CAR and HR¼ 2.05 ; p < .001 for DIPSS] and in SMF independently of Mysec-PM (HR¼ 6.48 ; p ¼ .022 for high CAR and HR¼ 2.63 ; p ¼ .013 for Mysec-PM) demonstrating its good prognostic potential. CAR seems to be an independent and prognostically relevant parameter, both in PMF and SMF, and might aid in timely recognition of most vulnerable patients.
Myeloproliferative neoplasm ; myelofibrosis ; C reactive protein ; albumin ; survival
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Podaci o izdanju
61 (12)
2020.
2969-2974
objavljeno
1042-8194
1029-2403
10.1080/10428194.2020.1789627