Virulence Characteristics of Escherichia coli Strains Causing Asymptomatic Bacteriuria (CROSBI ID 100688)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Vraneš, Jasmina ; Kružić, Vladimira ; Schoenwald, Slavko
engleski
Virulence Characteristics of Escherichia coli Strains Causing Asymptomatic Bacteriuria
Background: The objective of this study was to examine the expression of Escherichia coli virulence-associated factors among the strains isolated from a group of women with a history of recurrent urinary tract infections (UTIs), in whom asymptomatic bacteriuria (ABU) was detected at follow-up, and from a group of children without a history of previous UTI, in whom ABU was detected during the screening. Possible differences between the virulence potential of these strains were investigated. Materials and Methods: Hemolysin production, the ability to adhere to Buffalo green monkey cell line and hemagglutination (HA) ability of the ABU-associated E. coli strains were tested. E. coli strains isolated from patients with acute recurrent UTIs served as a comparison. Results: The well-known low virulence of strains isolated from patients with ABU was demonstrated. In contrast to strains isolated from recurrent uncomplicated UTIs, the ABUassociated strains were mostly nonhemolytic (75%), nonadherent (70%) and lacked HA ability (61%). HA ability was significantly more common among the strains isolated from children without a history of UTI than among the strains isolated from women with recurrent UTIs (2 = 9.97, p < 0.01), whereas the adherence and hemolytic abilities did not differ between the two ABU groups. Conclusion: A further prospective study is needed to determine whether the HA ability is the predictor of subsequent symptomatic UTI.
Urinary tract infection; pathogenesis; asymptomatic bacteriuria; Escherichia coli; virulence; chemotherapy
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano