Immunoglobulin G glycome composition in transition from premenopause to postmenopause (CROSBI ID 307176)
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Podaci o odgovornosti
Deriš, Helena ; Kifer, Domagoj ; Cindrić, Ana ; Petrović, Tea ; Cvetko, Ana ; Trbojević-Akmačić, Irena ; Kolčić, Ivana ; Polašek, Ozren ; Newson, Louise ; Spector, Tim ; Menni, Cristina ; Lauc, Gordan
engleski
Immunoglobulin G glycome composition in transition from premenopause to postmenopause
Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause. Using ultra-high- performance liquid chromatography, we analyzed IgG glycome composition in 5, 080 samples from 1940 pre-, peri-, and postmenopausal women. Statistically significant decrease in galactosylation and sialylation was observed in postmenopausal women. Furthermore, during the transition from pre- to postmenopausal period, the rate of increase in agalactosylated structures (0.051/yr ; 95%CI = 0.043-0.059, p < 0.001) and decrease in digalactosylated (-0.043/yr ; 95%CI = -0.050 to -0.037, p < 0.001) and monosialylated glycans (-0.029/yr ; 95%CI = -0.034 to -0.024, p < 0.001) were significantly higher than in either pre- or postmenopausal periods. The conversion to the more proinflammatory IgG glycome and the resulting decrease in the ability of IgG to suppress low-grade chronic inflammation may be an important molecular mechanism mediating the increased health risk in perimenopause and postmenopause.
Glycomics ; Molecular biology ; Reproductive medicine
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Podaci o izdanju
Povezanost rada
Biologija, Temeljne medicinske znanosti