Current Concepts of Psoriasis Immunopathogenesis (CROSBI ID 306854)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Vičić, Marijana ; Kaštelan, Marija ; Brajac, Ines ; Sotošek, Vlatka ; Prpić Massari, Larisa
engleski
Current Concepts of Psoriasis Immunopathogenesis
Psoriasis is a recurrent, chronic, immune- mediated, systemic inflammatory disease of the skin, joints, and other organic systems. After atopic dermatitis, chronic stationary psoriasis is the most common inflammatory skin disease, affecting an average of 2-4% of the world's population. The disease carries a significant burden due to its numerous comorbidities and the major impact on patients' social and emotional aspects of life. According to current knowledge, psoriasis is a multifactorial disease that occurs in genetically predisposed individuals under various environmental factors, which trigger an immune response disorder with a series of complex inflammatory cascades. The disease is initiated and maintained by mutual interaction of the innate and adaptive immune cells, primarily dendritic cells, T lymphocytes, and keratinocytes, whose leading role alternates at different stages of the disease, consisting mainly in the IL-23/Th17 pathway. Inflammatory events result in consequent epidermal and dermal changes and evolution of the characteristic psoriatic phenotype, respectively. This paper aims to present a comprehensive overview of current knowledge on psoriasis genetic and environmental etiological factors, immunopathogenesis, and the leading cellular and cytokine participants in the inflammatory pathways of this disease.
psoriasis ; etiology ; immunopathogenesis ; T lymphocytes ; dendritic cells ; keratinocytes ; macrophages ; NK cells ; NKT cells ; IL-23/Th17 pathway
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Podaci o izdanju
22 (21)
2021.
11574
14
objavljeno
1422-0067
10.3390/ijms222111574
Povezanost rada
Kliničke medicinske znanosti, Temeljne medicinske znanosti