engleski

PROPERTIES OF HYDROPHOBIC DEEP EUTECTIC SOLVENTS IMPORTANT FOR THEIR PHARMACEUTICAL APPLICATION

Deep Eutectic Solvents (DESs) are in the focus of fundamental, but also applicative researches in the field of Green Chemistry. Their green character arises from the fact that DESs are non-toxic and non-flammable, as well as easily synthetized from cheap and renewable compounds. Recently, a new window is opened with subclass of DESs, hydrophobic DESs (hDESs), which could be of great value for the pharmaceutical and cosmetic industry. hDESs can overpass the problems that occur with the compounds poorly soluble in water by increasing their solubility, permeability and bioavailability. In order to safely use it in aforementioned industries it is of great importance to test their cytotoxicity and their own permeability potential. Therefore, in the presented work we have synthetized eight hydrophobic DESs and evaluated their cytotoxic profile in vitro on two human cell lines CaCo-2 and HaCaT. The Parallel Artificial Membrane Permeability Assay (PAMPA) was applied as an in vitro model of passive permeation to determine potential of hDESs to be used as a solvent or a carrier for different compounds of interest.

hydrophobic DES, in vitro test, PAMPA, Cell line

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