engleski

Research and development of wound dressings with biodegradable textile carrier

Skin is a great barrier protecting human body which possesses excellent regenerative properties. Today there is almost no person who has not had a mechanical injury of the skin or mucosa during his life. Sometimes wounds do not heal in a timely fashion, and they require a special approach to healing. Such wounds are called chronic wounds and are treated with systemic and local treatment procedures. There is a large number of products on the market that are combined in treatment, which is expected given the different metabolism of patients (Actisorb Silver 220, Arglaes etc.). In some patients, biofilm is forming ; this process takes place very quickly, within a day or two and intensifies inflammation, inhibiting extracellular matrix deposition and tissue repair [1]. This condition places the patients in significant danger and recurrent surgical procedures (wound debridement or even tissue amputation). Existing wound care products have significantly improved the patient care but cannot address the multifactorial nature of impaired wound healing. The ideal wound dressings are supposed to cover the wound, preserve the body water content, be oxygen permeable to allow oxygen access to growing tissue, and prevent the growth of environmental pathogens without interfering with the wound healing [2]. By making dressings for chronic wounds in several layers with the newer methods of textile technology (3D fabrics, fabrics/knits/nonwoven of electrospun fibers) from biodegradable polymers (PGA, PLA, PDS) with active substances, it is possible to contribute to more successful healing of chronic wounds. Active substances (Ag+, metal/metal oxide nanoparticles, propolis, etc.) are released by different mechanisms of action (pH, chemical bonds, temperature) certainly contribute to the process of local treatment of chronic wounds. The utilized materials are biodegradable and immunocompatible, and do not support cell ingrowth and cellular adhesion so to avoid complications if removal is necessary.

medical textiles, wound dressings, biodegradable textile carrier

This work was financially fully supported by the Croatian Science Foundation, project IP-2019-04- 1381 under title „Antibacterial coating for biodegradable medicine materials ABBAMEDICA“. Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of Croatian Science Foundation.