engleski

APPLICATION OF FLOW MILI- AND MICROREACTORS IN THE SYNTHESIS OF HETEROCYCLIC RESVERATROL ANALOGUES

In organic chemistry, more and more attention is paid to synthesis in milli- and micro-flow systems (flow chemistry). This approach has numerous advantages over batch synthesis such as higher efficiency, environmental friendliness and safety and the advantage that all toxic and corrosive reagents are handeled in a closed system [1]. In this work, a series of reactions will be carried out for the synthesis of new heterocyclic resveratrol analogues by batch synthesis, and in milli- and micro-reactors in which the reaction conditions will be optimized to increase efficiency and safety and enhance the process. A selective and convenient way to form a carbon-carbon double bond is through the Wittig reaction and its modifications. This reaction is one of the most important and versatile reactions in organic chemistry for the synthesis of alkenes with unambiguous positioning of the double bond [2, 3]. An aldehyde and a Wittig salt are introduced into the reactor where they react by treatment with aqueous sodium hydroxide to form the corresponding unsaturated Wittig product. The results obtained by batch synthesis and flow synthesis were compared and presented in this work

mili and microreactory, synthesis, heterocyclic resveratrol analogue

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