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Potentiometric response characteristics of carbon paste electrode for maprotiline determination

In this paper, for the first time, carbon paste electrodes (CPE) were prepared for potentiometric quantitative determination of maprotiline, a second generation antidepressant [1]. A series of pastes of different composition and ratios of components were prepared. Dibutyl phthalate, dioctyl phthalate, 2-nitrophenyl octyl ether, bis(2-ethylhexyl) adipate and tris(2-ethylhexyl) phosphate were used as binders, whereas sodium tetraphenylborate, phosphotungstic acid, phosphomolybdic acid and ammonium reineckate were used as precipitating reagents to synthetize the ion association complexes (IAC). A 2.0 mm diameter Teflon holder made in laboratory [2], significantly reduced the consumption of paste components, since a lot of measurements could have been performed with 150 mg of paste, which was enough to examine all analytical parameters. Response characteristics of all electrodes were tested in 0.015 M acetate buffer solution (pH = 4.5) at room conditions. Unmodified CPEs showed no significant linearity, while some of CPEs with incorporated IAC and salt exhibited near-Nernstian slope over the linear dynamic range of 1.0×10-6 – 1.0×10-2 mol L-1 of maprotiline concentration. Some of the prepared CPEs showed better preliminary response characteristics than the response characteristics of PVC electrodes previously reported. [3]

maprotiline, percipitated reagents, carbon paste electrode, potentiometry

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