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Sjögren’s syndrome - immunological mechanisms, clinical presentation and management (CROSBI ID 448085)

Ocjenski rad | diplomski rad

Julia Anastasia Raith Sjögren’s syndrome - immunological mechanisms, clinical presentation and management / Markeljević, Jasenka (mentor); Zagreb, Hrvatska, Medicinski fakultet u Zagrebu, . 2021

Podaci o odgovornosti

Julia Anastasia Raith

Markeljević, Jasenka

engleski

Sjögren’s syndrome - immunological mechanisms, clinical presentation and management

Sjögren Syndrome (SS) is a chronic systemic autoimmune disease of unknown etiology, primarily affecting the exocrine glands. Clinically, this manifests as decreased secretion of lacrimal glands and salivary glands with a feeling of dry eyes (xerophthalmia) and a dry oral mucosa (xerostomia), as well as dryness of the mucous membranes of the respiratory, gastrointestinal, and urogenital systems. In addition to the glandular manifestations, extra glandular manifestations can also occur. These involve the musculoskeletal system, the interstitium of the lungs, internal organs, and the peripheral and central nervous systems. Primarily affecting women in their 5th and 6th decades of life, Sjögren’s syndrome is the most common autoimmune disease after rheumatoid arthritis (RA). The Immunopathogenesis of SS includes a dysregulation in the interaction of endogenous and exogenous factors at systemic and local levels in genetically predisposed individuals. Sjögren’s syndrome may manifest as primary Sjögrens syndrome (pSS) or secondary if associated with other autoimmune diseases. The diagnostic procedure is based on the diagnostic criteria established by the American-European Consensus Group in 2002, which have been revised several times since then and include a variety of diagnostic tests, including the Schirmer test, serology, biopsy, and imaging. In the past, the treatment of Sjögren’s syndrome has mainly focused on relieving the symptoms and suppressing the immune system, more recently the subject of research has been immunotherapy, biological therapy, and stem cell therapy. As an alternative therapy, Chinese medicine has shown a positive effect on patients with Sjögren Syndrome

Sjogren's syndrome ; sicca symptoms ; autoimmune diseases

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Podaci o izdanju

32

16.07.2021.

obranjeno

Podaci o ustanovi koja je dodijelila akademski stupanj

Medicinski fakultet u Zagrebu

Zagreb, Hrvatska

Povezanost rada

Kliničke medicinske znanosti

Poveznice