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Pregled bibliografske jedinice broj: 1181171

PBDEs found in house dust impact human lung epithelial cell homeostasis


Zandona, Antonio; Jagić, Karla; Dvoršćak, Marija; Madunić, Josip; Klinčić, Darija; Katalinić, Maja
PBDEs found in house dust impact human lung epithelial cell homeostasis // Toxics, 10 (2022), 97-112 doi:10.3390/toxics10020097 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1181171 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
PBDEs found in house dust impact human lung epithelial cell homeostasis

Autori
Zandona, Antonio ; Jagić, Karla ; Dvoršćak, Marija ; Madunić, Josip ; Klinčić, Darija ; Katalinić, Maja

Izvornik
Toxics (2305-6304) 10 (2022); 97-112

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
PBDEs ; A549 ; house dust ; cytotoxicity ; viability ; prolonged exposure

Sažetak
The toxicity of eight polybrominated diphenyl ethers (PBDEs) congeners detected in environmental and biological samples (BDE-28, -47, -99, -100, -153, -154, -183, and -209) was evaluated on the epithelial lung cells. Exposure to these PBDEs increased membrane disruption and a release of lactate dehydrogenase, accompanied by oxidative stress in cells through the formation of reactive oxygen species (ROS) and a decrease in mitochondrial membrane potential. Interestingly, some of the tested PBDEs increased apoptotic markers as well. For several congeners, the observed toxicity was time dependent, meaning that even smaller concentrations of these compounds will have negative effects over time. Such time- dependent toxicity was also confirmed for cell treatment with a real house dust sample extract. This could be indicative with regard to the constant exposure to a mixture of PBDE congeners through different pathways in the organism and thereby presenting a risk for human health. As such, our findings point to the importance of further studies on the negative effects of PBDEs to understand their mechanism of action in detail.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Projekti:
UIP-2017-05-7260 - MOLEKULARNI MEHANIZMI TOKSIČNOSTI PROTUOTROVA I POTENCIJALNIH LIJEKOVA (CellToxTargets) (Katalinić, Maja, HRZZ - 2017-05) ( POIROT)
UIP-2017-05-6713 - Razvoj, validacija i primjena analitičkih metoda za određivanje PBDE-a (DeValApp) (Klinčić, Darija, HRZZ - 2017-05) ( POIROT)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Zandona, Antonio; Jagić, Karla; Dvoršćak, Marija; Madunić, Josip; Klinčić, Darija; Katalinić, Maja
PBDEs found in house dust impact human lung epithelial cell homeostasis // Toxics, 10 (2022), 97-112 doi:10.3390/toxics10020097 (međunarodna recenzija, članak, znanstveni)
Zandona, A., Jagić, K., Dvoršćak, M., Madunić, J., Klinčić, D. & Katalinić, M. (2022) PBDEs found in house dust impact human lung epithelial cell homeostasis. Toxics, 10, 97-112 doi:10.3390/toxics10020097.
@article{article, author = {Zandona, Antonio and Jagi\'{c}, Karla and Dvor\v{s}\'{c}ak, Marija and Maduni\'{c}, Josip and Klin\v{c}i\'{c}, Darija and Katalini\'{c}, Maja}, year = {2022}, pages = {97-112}, DOI = {10.3390/toxics10020097}, keywords = {PBDEs, A549, house dust, cytotoxicity, viability, prolonged exposure}, journal = {Toxics}, doi = {10.3390/toxics10020097}, volume = {10}, issn = {2305-6304}, title = {PBDEs found in house dust impact human lung epithelial cell homeostasis}, keyword = {PBDEs, A549, house dust, cytotoxicity, viability, prolonged exposure} }
@article{article, author = {Zandona, Antonio and Jagi\'{c}, Karla and Dvor\v{s}\'{c}ak, Marija and Maduni\'{c}, Josip and Klin\v{c}i\'{c}, Darija and Katalini\'{c}, Maja}, year = {2022}, pages = {97-112}, DOI = {10.3390/toxics10020097}, keywords = {PBDEs, A549, house dust, cytotoxicity, viability, prolonged exposure}, journal = {Toxics}, doi = {10.3390/toxics10020097}, volume = {10}, issn = {2305-6304}, title = {PBDEs found in house dust impact human lung epithelial cell homeostasis}, keyword = {PBDEs, A549, house dust, cytotoxicity, viability, prolonged exposure} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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