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izvor podataka: crosbi

Serum cytokines and their predictive value in pulmonary involvement of systemic sclerosis. (CROSBI ID 306159)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Becker MO ; Radic M ; Schmidt K ; Huscher D ; Riedlinger A ; Michelfelder M ; Meisel C ; Ewert R ; Burmester GR ; Riemekasten G. Serum cytokines and their predictive value in pulmonary involvement of systemic sclerosis. // Sarcoidosis vasculitis and diffuse lung diseases, 36 (2019), 4; 274-284. doi: 10.36141/svdld.v36i4.7612

Podaci o odgovornosti

Becker MO ; Radic M ; Schmidt K ; Huscher D ; Riedlinger A ; Michelfelder M ; Meisel C ; Ewert R ; Burmester GR ; Riemekasten G.

engleski

Serum cytokines and their predictive value in pulmonary involvement of systemic sclerosis.

Objective: To identify serum cytokines which predict mortality and/or disease progression in patients with systemic sclerosis, especially with pulmonary involvement. Methods: Serum cytokines (IL-6, IL-7, IL- 8, IL-10, CCL2, CCL4, TGF-β, TNF- α) were measured in 125 SSc patients, who were recruited and observed in our outpatient clinic. Of these, 60 had pulmonary involvement, classified as either interstitial lung disease (ILD, 43 patients), pulmonary arterial hypertension (PAH, 7 patients) or pulmonary hypertension and ILD (PH- ILD, 10 patients). The association of serum cytokines with clinical features was analysed and their correlation with BAL cytokines measured in a subset of SSc patients with ILD. Results: Serum cytokines were detected at dif- ferent levels: high (TGF-β, median 287.5 pg/ml ; CCL2, median 89.7 pg/ml ; CCL4, median 104.2 pg/ml), low (IL-6, median 3.2 pg/ml ; IL-7 median 2.3 pg/ml ; IL-8, median 5.2 pg/ml ; TNF-α, median 0 pg/ml but with a bimodal distribution) and very low (IL-10, median 0.4 pg/ml). IL-6 and IL-7 were predictive for death in a Cox regression analysis in all SSc patients as well as in all patients with pulmonary involvement ; IL-6 was predictive for mortality in SSc- ILD patients. In a multivariate analysis, cytokine levels could also predict a change in lung function, e.g. IL-7 was a predictor for a decline of diffusion capacity (DLCO) by 20 or 30% in ILD patients. In a subset of ILD patients, serum cytokines were compared to BAL cytokines, but revealed only few correlations. Conclusion: In conclusion, the analysis of serum cytokines implicates a role as biomarkers, distinct from BAL.

systemic sclerosis, cytokines, chemokines, lung involvement, survival

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Podaci o izdanju

36 (4)

2019.

274-284

objavljeno

2532-179X

10.36141/svdld.v36i4.7612

Povezanost rada

Kliničke medicinske znanosti

Poveznice