engleski

Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes

Intracerebroventricular (icv) administration of betacytotoxics alters brain monoamine neurotransmission, without producing hyperglycemia. By means of in situ hybridization, we have investigated the expression of dopamine, noradrenaline and serotonin transporter (DAT, NAT, 5-HTT, respectively) mRNAs, in the brain of alloxan- and streptozotocin-icv treated rats. We found alterations of all three monoamine transporter genes expression in various brain raegions. Alterations were region-specific, monoamine-specific and related to the duration of diabetes. Changes may suggest altered response to antidepressants in streptozotocin-icv treated rats, used as an animal model of sporadic Alzheimer's disease.

alloxan; streptozotocin; monoamine transporter; brain

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