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Pregled bibliografske jedinice broj: 1180236

Long-term effects of melatonin and resveratrol on aging rats: A multi-biomarker approach


Breljak, Davorka; Micek, Vedran; Gerić, Marko; Gajski, Goran; Kralik Oguić Saša; Rašić, Dubravka; Karaica, Dean; Vrhovac Madunić, Ivana; Ljubojević, Marija; Orct, Tatjana et al.
Long-term effects of melatonin and resveratrol on aging rats: A multi-biomarker approach // Mutation research. Genetic toxicology and environmental mutagenesis, 876–877 (2022), 1-11 doi:10.1016/j.mrgentox.2022.503443 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1180236 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Long-term effects of melatonin and resveratrol on aging rats: A multi-biomarker approach

Autori
Breljak, Davorka ; Micek, Vedran ; Gerić, Marko ; Gajski, Goran ; Kralik Oguić Saša ; Rašić, Dubravka ; Karaica, Dean ; Vrhovac Madunić, Ivana ; Ljubojević, Marija ; Orct, Tatjana ; Jurasović, Jasna ; Novak Jovanović, Ivana ; Peraica, Maja ; Nanić, Lucia ; Rubelj, Ivica ; Sabolić, Ivan

Izvornik
Mutation research. Genetic toxicology and environmental mutagenesis (1383-5718) 876–877 (2022); 1-11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ageing ; Antioxidants ; Comet assay ; Geroprotectors ; Malondialdehyde ; Polyphenols

Sažetak
Aging-related impaired body structure and functions may be, at least partially, caused by elevated oxidative stress. Melatonin (MEL) and resveratrol (RSV) may act as antioxidant and anti- aging compounds, but these actions in experimental animals and humans are controversial. Herein, a rat model of aging was used to study the long-term sex-related effects of MEL and RSV treatment on body mass and blood/plasma parameters of DNA damage, oxidative status (glutathione and malondialdehyde levels), and concentrations of sex hormones. Starting from the age of 3mo, for the next 9mo or 21mo male and female Wistar rats (n = 4–7 per group) were given water to drink (controls) or 0.1 % ethanol in water (vehicle), or MEL or RSV (each 10 mg/L vehicle). DNA damage in whole blood cells was tested by comet assay, whereas in plasma, glutathione, malondialdehyde, and sex hormones were determined by established methods. Using statistical analysis of data by ANOVA/Scheffe post hoc, we observed a similar sex- and aging-dependent rise of body mass in both sexes and drop of plasma testosterone in control and vehicle-treated male rats, whose pattern remained unaffected by MEL and RSV treatment. Compared with controls, all other parameters remained largely unchanged in aging and differently treated male and female rats. We concluded that the sex- and aging-related pattern of growth and various blood parameters in rats were not affected by the long-term treatment with MEL and RSV at the estimated daily doses (300−400 μg/kg b.m.) that exceed usual moderate consumption in humans.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
IP-2013-11-1481 - Starosno-ovisna ekspresija membranskih prijenosnika u štakora (AGEMETAR) (Sabolić, Ivan, HRZZ - 2013-11) ( POIROT)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Breljak, Davorka; Micek, Vedran; Gerić, Marko; Gajski, Goran; Kralik Oguić Saša; Rašić, Dubravka; Karaica, Dean; Vrhovac Madunić, Ivana; Ljubojević, Marija; Orct, Tatjana et al.
Long-term effects of melatonin and resveratrol on aging rats: A multi-biomarker approach // Mutation research. Genetic toxicology and environmental mutagenesis, 876–877 (2022), 1-11 doi:10.1016/j.mrgentox.2022.503443 (međunarodna recenzija, članak, znanstveni)
Breljak, D., Micek, V., Gerić, M., Gajski, G., Kralik Oguić Saša, Rašić, D., Karaica, D., Vrhovac Madunić, I., Ljubojević, M. & Orct, T. (2022) Long-term effects of melatonin and resveratrol on aging rats: A multi-biomarker approach. Mutation research. Genetic toxicology and environmental mutagenesis, 876–877, 1-11 doi:10.1016/j.mrgentox.2022.503443.
@article{article, author = {Breljak, Davorka and Micek, Vedran and Geri\'{c}, Marko and Gajski, Goran and Ra\v{s}i\'{c}, Dubravka and Karaica, Dean and Vrhovac Maduni\'{c}, Ivana and Ljubojevi\'{c}, Marija and Orct, Tatjana and Jurasovi\'{c}, Jasna and Novak Jovanovi\'{c}, Ivana and Peraica, Maja and Nani\'{c}, Lucia and Rubelj, Ivica and Saboli\'{c}, Ivan}, year = {2022}, pages = {1-11}, DOI = {10.1016/j.mrgentox.2022.503443}, keywords = {Ageing, Antioxidants, Comet assay, Geroprotectors, Malondialdehyde, Polyphenols}, journal = {Mutation research. Genetic toxicology and environmental mutagenesis}, doi = {10.1016/j.mrgentox.2022.503443}, volume = {876–877}, issn = {1383-5718}, title = {Long-term effects of melatonin and resveratrol on aging rats: A multi-biomarker approach}, keyword = {Ageing, Antioxidants, Comet assay, Geroprotectors, Malondialdehyde, Polyphenols} }
@article{article, author = {Breljak, Davorka and Micek, Vedran and Geri\'{c}, Marko and Gajski, Goran and Ra\v{s}i\'{c}, Dubravka and Karaica, Dean and Vrhovac Maduni\'{c}, Ivana and Ljubojevi\'{c}, Marija and Orct, Tatjana and Jurasovi\'{c}, Jasna and Novak Jovanovi\'{c}, Ivana and Peraica, Maja and Nani\'{c}, Lucia and Rubelj, Ivica and Saboli\'{c}, Ivan}, year = {2022}, pages = {1-11}, DOI = {10.1016/j.mrgentox.2022.503443}, keywords = {Ageing, Antioxidants, Comet assay, Geroprotectors, Malondialdehyde, Polyphenols}, journal = {Mutation research. Genetic toxicology and environmental mutagenesis}, doi = {10.1016/j.mrgentox.2022.503443}, volume = {876–877}, issn = {1383-5718}, title = {Long-term effects of melatonin and resveratrol on aging rats: A multi-biomarker approach}, keyword = {Ageing, Antioxidants, Comet assay, Geroprotectors, Malondialdehyde, Polyphenols} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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