engleski

Rapid overlapping of Single Molecule High-Fidelity Sequencing Data

In 2019, Pacific Bioscience introduced highly accurate long-read sequencing (HiFi sequencing), a paradigm that combines concepts from traditional short and long error-prone reads technologies. Long lengths and high base-level resolution characterize the HiFi fragments. These characteristics can be utilized to design algorithms that are less sensitive to errors. In this article, we present the novel algorithm for HiFi reads mapping. The algorithm is based on suffix arrays and a standard seed-chain-align procedure. We will analyze the performance and accuracy of the developed tool and compare it to state-of-the-art algorithms.

HiFi PacBio reads ; DNA sequencing ; suffix array

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