EFFECTS OF CHANGES IN GLYCOLIPID CELL MEMBRANE COMPOSITION ON THE COMPOSITION OF LIPID RAFTS IN SH-SY5Y HUMAN NEUROBLASTOMA CELL LINE (CROSBI ID 447836)
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Podaci o odgovornosti
Milorad Zjalić
prof.dr.sc. Marija Heffer dr.med ; prof.dr.sc. Marianna Pap dr.med.
engleski
EFFECTS OF CHANGES IN GLYCOLIPID CELL MEMBRANE COMPOSITION ON THE COMPOSITION OF LIPID RAFTS IN SH-SY5Y HUMAN NEUROBLASTOMA CELL LINE
Interfering with glycolipid biosynthesis caused dose-dependent cell death and change in morphology. Miglustat caused expected morphology changes in the form of neurite elongation, whilst CBE in sub-effective concentrations had the reverse effect on cell morphology. The insulin signaling pathway was upregulated with all treatments. Cells demonstrated changes in neuroplasticity and different responses to induced metabolic stress depending on which inhibitor was applied.
SH-SY5Y ; miglustat ; conduritol B epoxide ; insulin ; neuroplasticity
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20.07.2021.
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