Plasma levels of soluble TGF ß receptor type III: no apparent promise as a marker in acute pancreatitis (CROSBI ID 305736)
Prilog u časopisu | kratko priopćenje | međunarodna recenzija
Podaci o odgovornosti
Salai, Grgur ; Zelenika, Marko ; Hrkač, Stela ; Trkulja, Vladimir ; Bilandžić, Joško ; Grgurević, Ivica ; Novak, Ruđer ; Grgurević, Lovorka
engleski
Plasma levels of soluble TGF ß receptor type III: no apparent promise as a marker in acute pancreatitis
Aim: To assess the potential of the soluble transforming growth factor β receptor type III (sTGFβrIII), a key regulator in TGFβ signaling, as a biomarker for diagnosis and stratification of patients with acute pancreatitis (AP). Methods: In this small prospective pilot study, patients' (N=22) plasma samples were obtained at three time points: the first and fourth day of hospitalization and the day of hospital discharge. Healthy controls' plasma (N=25) was obtained at a single time point. Concentration of sTGFβrIII in plasma was determined by ELISA. Data were analyzed by fitting linear or linear mixed models. Results: Plasma sTGFβrIII levels at presentation (day 1) were similar in AP patients and healthy participants, irrespectively of the disease severity. sTGFβrIII levels in patients were constant during hospital stay. Conclusion: These observations do not support further evaluation of plasma sTGFβrIII levels in this setting, but do not exclude a potential biological role of TGFβ and membrane-bound TGFβrIII in AP pathophysiology.
TGF beta receptor type III ; pancreatitis
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
62 (3)
2021.
264-269
objavljeno
0353-9504
1332-8166
10.3325/cmj.2021.62.264
Povezanost rada
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)