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Early in-hospital initiation and optimization of comprehensive disease-modifying pharmacotherapy in patients with heart failure with reduced ejection fraction: a time for the paradigm shift (CROSBI ID 305310)

Prilog u časopisu | kratko priopćenje | međunarodna recenzija

Borovac, Josip Anđelo Early in-hospital initiation and optimization of comprehensive disease-modifying pharmacotherapy in patients with heart failure with reduced ejection fraction: a time for the paradigm shift // Expert review of cardiovascular therapy, 20 (2022), 2; 91-94. doi: 10.1080/14779072.2022.2039626

Podaci o odgovornosti

Borovac, Josip Anđelo

engleski

Early in-hospital initiation and optimization of comprehensive disease-modifying pharmacotherapy in patients with heart failure with reduced ejection fraction: a time for the paradigm shift

This paper synthesizes and organizes the latest relevant data regarding the novel pharmacotherapies for the clinical syndrome of heart failure with reduced ejection fraction (HFrEF). The main goal of the article is to emphasize the importance of the introduction of all foundational drugs in patients with HFrEF during hospitalization or at least before hospital discharge. Furthermore, based on the available data, this manuscript provides a putative scheme/pathway for rapid initiation and subsequent up-titration of these crucial disease-modifying therapies that have demonstrated a profound impact on mortality and morbidity in this population. This is a novel concept that replaces traditional, slow, and sequential initiation of life-saving therapies.

beta-blockers ; heart failure with reduced ejection fraction ; HFrEF ; mineralocorticoid antagonists ; MRA ; sacubitril/valsartan ; ARNI ; quadruple therapy ; SGLT2 ; sodium glucose co-transporter 2 ; outcomes ; morbidity ; mortality ; uptitration ; acute decompensated heart failure ; evidence-based treatment ; RCT

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Podaci o izdanju

20 (2)

2022.

91-94

objavljeno

1477-9072

1744-8344

10.1080/14779072.2022.2039626

Povezanost rada

Kliničke medicinske znanosti

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