The antimicrobial activities of oleuropein and hydroxytyrosol (CROSBI ID 72153)
Prilog u knjizi | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Zorić, Nataša ; Kosalec, Ivan
engleski
The antimicrobial activities of oleuropein and hydroxytyrosol
Several studies have reported that olive leaf extract and its constituents, particularly oleuropein and hydroxytyrosol, have health benefits including antioxidant and antimicrobial properties. Oleuropein and hydroxytyrosol have significant in vitro activity against fungi including opportunistic pathogen Candida albicans. Both compounds target virulence factors essential for the establishment of C. albicans infection. Both biomolecules express wide antibacterial activity in vitro. On the bacterial model Staphylococcus aureus, different targets have been detected. Oleuropein and hydroxytyrosol also interact with biofilm formation and could potentiate the activity of ampicillin. Considering the growing resistance to existing therapeutics has triggered the need for the development of new antimicrobial drugs, based on the presented results in this chapter, it seems that oleuropein and its derivative hydroxytyrosol could be considered as promising candidates for the treatment and/or prevention of candidiasis, and local infections caused by bacteria.
antimicrobial activity ; oleuropein ; hydroxytyrosol ; Olea europea ; olive leaf extract
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Podaci o prilogu
75-89.
objavljeno
10.1007/978-3-030-83504-0_5
Podaci o knjizi
Promising antimicrobials from natural products
Rai, Mahendra ; Kosalec, Ivan
Cham: Springer
2022.
978-3-030-83503-3