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Development and characterization of antibacterial coating with nanoparticles active against MRSA and MSSA

Covid-19 is not the only threat to the global human health. It is estimated that by the year 2050, from the infections caused by antibiotic-resistant bacteria, more people could die than from AIDS, tuberculosis and viral hepatitis together. Only in Europe 25 000 deaths per year and costs over € 1.5 billion are the consequences of the resistant microorganisms activity. Therefore, in this work new antimicrobial materials containing nanoparticles active against Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin- sensitive Staphylococcus aureus (MSSA), microorganism strains resistant to antibiotics, are developed. Antimicrobial water-repellent coatings are intended for materials foreseen as: bedding hospital items, disposable antimicrobial lining and bandages for chronic wounds. In the development of the antimicrobial formulation, we apply the Response surface methodology (RSM) and mathematical modeling for predicting the optimal antimicrobial activity of nanoparticles and their mixtures. The thus-calculated antimicrobial mixtures are applied on the surface of biodegradable polymers (textiles or 3D printed surfaces) by sol-gel process. Polymers are characterized by different spectroscopic, microscopic and chromatographic methods and investigated for their newly obtained functional properties (water repellency, antimicrobial efficiency and others). Our results show that by applying RSM methodology and mathematical modeling, and by changing the process parameters excellent water repellency is achieved [1], as well as a very good antibacterial efficiency against MRSA and MSSA microorganisms [2]. In our future activities we plan to optimize the antimicrobial properties further in order to enhance the efficiency and reduce the time required for total antimicrobial effects in time interval shorter than few hours.

Development and characterization of antibacterial coating with nanoparticles active against MRSA and MSSA

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