engleski

Progesterone receptor genetic variants in pregnant women and fetuses as possible predictors of spontaneous premature birth

Premature birth (PTB) is defined as a live birth before 37 weeks of gestation. Besides its association with mortality, there are both acute and chronic morbidities associated with PTB, including long-term sequelae such as cognitive and motor delays. One of the recognized risk factors for PTB is a maternal and/or fetal genetic predispositio. One of main pathways involved in uterine quiescence is progesterone (P4) pathway. A number of single nucleotide polymorphisms (SNPs) have been described in human PGR.The aim of this study was to evaluate the roles of four selected genetic variations in fetal and maternal progesterone receptor gene (PGR) and to identify women who may have higher or lower odds for PTB compared to the general population.

prijevremeni porod, progesteron, progesteronski receptori, polimorfizam jednog nukleotida

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