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Pregled bibliografske jedinice broj: 1174050

Metabolism of direct-acting antiviral agents (DAAs) in Hepatitis C therapy: a review of the literature


Mikolašević, Ivana; Filipec Kanižaj, Tajana; Božić, Dorotea; Puž, Petra; Shapeski, Sanja S.; Puljiz, Željko; Radić-Krišto, Delfa; Lalovac, Miloš; Mijić, Maja; Delija, Božena et al.
Metabolism of direct-acting antiviral agents (DAAs) in Hepatitis C therapy: a review of the literature // Current drug metabolism, 22 (2021), 2; 89-98 doi:10.2174/1389200221999201214224126 (međunarodna recenzija, pregledni rad, stručni)


CROSBI ID: 1174050 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Metabolism of direct-acting antiviral agents (DAAs) in Hepatitis C therapy: a review of the literature

Autori
Mikolašević, Ivana ; Filipec Kanižaj, Tajana ; Božić, Dorotea ; Puž, Petra ; Shapeski, Sanja S. ; Puljiz, Željko ; Radić-Krišto, Delfa ; Lalovac, Miloš ; Mijić, Maja ; Delija, Božena ; Jurić, Toni ; Bogadi, Ivan ; Virović-Jukić, Lucija

Izvornik
Current drug metabolism (1389-2002) 22 (2021), 2; 89-98

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
Hepatitis C ; cirrhosis ; direct-acting antivirals ; drug-drug interactions ; hepatocellular carcinoma ; liver transplantation.

Sažetak
Background: Hepatitis C virus (HCV) infection is still one of the leading causes of chronic liver disease, with chronically infected making up approximately 1% of the global population. Of those infected, 70% (55-85%) will develop chronic HCV infection. Chronic HCV infection causes substantial morbidity and mortality, with complications including cirrhosis, end-stage liver disease, hepatocellular carcinoma, and eventually death. Objective: Therapeutic options for chronic HCV infection have evolved dramatically since 2014, with a translation from pegylated interferon and ribavirin (associated with suboptimal cure and high treatment-related toxicity) to oral direct- acting antiviral treatment. There are four classes of direct-acting antivirals which differ by their mechanism of action and therapeutic target. They are all pointed to proteins that form the cytoplasmic viral replication complex. Multiple studies have demonstrated that direct-acting antiviral therapy is extremely well tolerated, highly efficacious, with few side effects. Methods: We performed an indexed MEDLINE search with keywords regarding specific direct-acting antiviral regimes and their pharmacokinetics, drug-drug interactions, and metabolism in specific settings of pregnancy, lactation, liver cirrhosis, liver transplantation and HCC risk, kidney failure and kidney transplantation. Results: We present a comprehensive overview of specific direct-acting antiviral metabolism and drug-drug interaction issues in different settings. Conclusion: Despite its complex pharmacokinetics and the possibility of drug-drug interactions, direct-acting antivirals are highly efficacious in providing viral clearance, which is an obvious advantage compared to possible interactions or side effects. They should be administered cautiously in patients with other comorbidities, and with tight control of immunosuppressive therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinička bolnica "Merkur",
Medicinski fakultet, Rijeka,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
KBC Split,
Medicinski fakultet, Split,
Klinički bolnički centar Rijeka

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Mikolašević, Ivana; Filipec Kanižaj, Tajana; Božić, Dorotea; Puž, Petra; Shapeski, Sanja S.; Puljiz, Željko; Radić-Krišto, Delfa; Lalovac, Miloš; Mijić, Maja; Delija, Božena et al.
Metabolism of direct-acting antiviral agents (DAAs) in Hepatitis C therapy: a review of the literature // Current drug metabolism, 22 (2021), 2; 89-98 doi:10.2174/1389200221999201214224126 (međunarodna recenzija, pregledni rad, stručni)
Mikolašević, I., Filipec Kanižaj, T., Božić, D., Puž, P., Shapeski, S., Puljiz, Ž., Radić-Krišto, D., Lalovac, M., Mijić, M. & Delija, B. (2021) Metabolism of direct-acting antiviral agents (DAAs) in Hepatitis C therapy: a review of the literature. Current drug metabolism, 22 (2), 89-98 doi:10.2174/1389200221999201214224126.
@article{article, author = {Mikola\v{s}evi\'{c}, Ivana and Filipec Kani\v{z}aj, Tajana and Bo\v{z}i\'{c}, Dorotea and Pu\v{z}, Petra and Shapeski, Sanja S. and Puljiz, \v{Z}eljko and Radi\'{c}-Kri\v{s}to, Delfa and Lalovac, Milo\v{s} and Miji\'{c}, Maja and Delija, Bo\v{z}ena and Juri\'{c}, Toni and Bogadi, Ivan and Virovi\'{c}-Juki\'{c}, Lucija}, year = {2021}, pages = {89-98}, DOI = {10.2174/1389200221999201214224126}, keywords = {Hepatitis C, cirrhosis, direct-acting antivirals, drug-drug interactions, hepatocellular carcinoma, liver transplantation.}, journal = {Current drug metabolism}, doi = {10.2174/1389200221999201214224126}, volume = {22}, number = {2}, issn = {1389-2002}, title = {Metabolism of direct-acting antiviral agents (DAAs) in Hepatitis C therapy: a review of the literature}, keyword = {Hepatitis C, cirrhosis, direct-acting antivirals, drug-drug interactions, hepatocellular carcinoma, liver transplantation.} }
@article{article, author = {Mikola\v{s}evi\'{c}, Ivana and Filipec Kani\v{z}aj, Tajana and Bo\v{z}i\'{c}, Dorotea and Pu\v{z}, Petra and Shapeski, Sanja S. and Puljiz, \v{Z}eljko and Radi\'{c}-Kri\v{s}to, Delfa and Lalovac, Milo\v{s} and Miji\'{c}, Maja and Delija, Bo\v{z}ena and Juri\'{c}, Toni and Bogadi, Ivan and Virovi\'{c}-Juki\'{c}, Lucija}, year = {2021}, pages = {89-98}, DOI = {10.2174/1389200221999201214224126}, keywords = {Hepatitis C, cirrhosis, direct-acting antivirals, drug-drug interactions, hepatocellular carcinoma, liver transplantation.}, journal = {Current drug metabolism}, doi = {10.2174/1389200221999201214224126}, volume = {22}, number = {2}, issn = {1389-2002}, title = {Metabolism of direct-acting antiviral agents (DAAs) in Hepatitis C therapy: a review of the literature}, keyword = {Hepatitis C, cirrhosis, direct-acting antivirals, drug-drug interactions, hepatocellular carcinoma, liver transplantation.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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