engleski

Maleš J, Mendeš T, Včev A, Zubčić Ž, Mihalj H, Šestak A et al. Inverted papilloma: A twenty yers retrospective study from one institution. Med. Jadertina. 2021; 51(29.131- 6.

We have been treating endoscopically different kinds of inverted papilloma including malignant inverted papilloma since 1995. This is a retrospective study which demonstrates our experience in the treatment of inverted papilloma. Inverted papilloma is defined as a benign, locally aggressive tumor with malignant transformation and frequent recurrence. The aim of the study is to investigate whether the malignancy starts developing at the beginning of disease or later, and whether we can consider deviated septum as a etiologic factor of inverted papilloma. We also wanted to show endoscopic endonasal surgery as a method of choice in the treatment of inverted papilloma. Data in the period from 1998 to 2017 were analyzed retrospectively. Out of a total number of 62 patients, three (4.8%) were diagnosed with inverted papilloma with squamous cell carcinoma in some part of the lesion and 59 (95.2%) were diagnosed like inverted papilloma. The patients diagnosed with inverted papilloma and with squamous cell carcinoma were significantly older than the patients diagnosed with IP (Mann- Whitney U test, p = 0.006). The most common localization of primary tumor was the maxillary sinus. The dominant symptom in patients with inverted papilloma was epistaxis in more than half of our patients, followed by nasal obstruction in more than one third of our patients. We compared our results with the results from literature. Our results show a low percentage of malignant transformation only in three cases (4.8%). The obtained result corresponds to previous studies, with values below the average obtained in other studies. Finally, the endoscopic endonasal approach is the contemporary gold standard in the treatment of inverted papilloma.

inverted papilloma, malignant transformation, endoscopic endonasal approach

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