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Photokilling Squamous Carcinoma Cells SCCVII with Ultrafine Particles of Selected Metal Oxydes


Ivanković, Siniša; Gotić, Marijan; Jurin, Mislav; Musić, Svetozar
Photokilling Squamous Carcinoma Cells SCCVII with Ultrafine Particles of Selected Metal Oxydes // Journal of sol-gel science and technology, 27 (2003), 225-233 doi:10.1023/A:1023715004575 (međunarodna recenzija, članak, znanstveni)


Naslov
Photokilling Squamous Carcinoma Cells SCCVII with Ultrafine Particles of Selected Metal Oxydes

Autori
Ivanković, Siniša ; Gotić, Marijan ; Jurin, Mislav ; Musić, Svetozar

Izvornik
Journal of sol-gel science and technology (0928-0707) 27 (2003); 225-233

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
TiO2 ; WO3 ; iron-doped TiO2 ; ultrafine particles ; cancer cells ; photokilling effect

Sažetak
The ability of ultrafine particles of TiO2, WO3 and iron-doped TiO2 to kill cancer cells in the presence of UV irradiation was investigated. The best photokilling effect on carcinoma cells SCVII cultured in vitro showed iron-doped TiO2 ultrafine particles synthetized by the sol-gel procedure with starting chemicals Ti(IV)-isopropoxide and anhydrous Fe(II)-acetate. It was found that a small particle size and high dispersity influenced citotoxicity and photokilling efficiency. The remarcable photokilling effect of highly iron-doped TiO2 ultrafine particles (the molar ratio Fe/Ti=0.136) in the presence of UV irradiation was observed. The influence of ultrafine metal oxide particles on the inhibition of cancer cell prolifeartion was measured using 3H-thymidine incorporation test. The possible mechanisms involved in the photokilling of carcinoma cells with ultrafine particles of selected metal oxydes was discussed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0098062
0098099

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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