Photokilling Squamous Carcinoma Cells SCCVII with Ultrafine Particles of Selected Metal Oxydes (CROSBI ID 100477)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Ivanković, Siniša ; Gotić, Marijan ; Jurin, Mislav ; Musić, Svetozar
engleski
Photokilling Squamous Carcinoma Cells SCCVII with Ultrafine Particles of Selected Metal Oxydes
The ability of ultrafine particles of TiO2, WO3 and iron-doped TiO2 to kill cancer cells in the presence of UV irradiation was investigated. The best photokilling effect on carcinoma cells SCVII cultured in vitro showed iron-doped TiO2 ultrafine particles synthetized by the sol-gel procedure with starting chemicals Ti(IV)-isopropoxide and anhydrous Fe(II)-acetate. It was found that a small particle size and high dispersity influenced citotoxicity and photokilling efficiency. The remarcable photokilling effect of highly iron-doped TiO2 ultrafine particles (the molar ratio Fe/Ti=0.136) in the presence of UV irradiation was observed. The influence of ultrafine metal oxide particles on the inhibition of cancer cell prolifeartion was measured using 3H-thymidine incorporation test. The possible mechanisms involved in the photokilling of carcinoma cells with ultrafine particles of selected metal oxydes was discussed.
TiO2 ; WO3 ; iron-doped TiO2 ; ultrafine particles ; cancer cells ; photokilling effect
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Podaci o izdanju
27
2003.
225-233
objavljeno
0928-0707
10.1023/A:1023715004575